摘要
外泌体是细胞内多囊泡体,直径约70~120 nm,与细胞膜融合后释放到细胞外基质中,可由任何类型的细胞释放。外泌体通过转运蛋白和核酸介导细胞间通信。根据细胞来源和靶细胞的不同,外泌体可以发挥免疫调节作用,也可以作为疾病的生物标志物和药物传递的载体,在自身免疫病的发病机制研究和免疫治疗应用中发挥重要作用。文章针对外泌体在自身免疫病发病机制研究及诊断和治疗中的应用进展进行综述。
Exosomes are multivesicular bodies(70120nm),and can be released by any type of cells after fusion with cell membranes.Exosomes mediate intercellular communication via transport proteins and nucleic acids,participating in a variety of physiological and pathological processes.According to the originated cells and target cells,exosomes play an important role in immunoregulation,serve as a biomarker for disease,a carrier for drug delivery,target of the pathogenesis of autoimmune diseases and immunotherapy.In this review,we will summarize current research advances of exosomes in immunoregulation,pathogenesis,diagnosis and therapeutics of autoimmune diseases.
作者
于娟
张立平
孙宁
李晓军
YU Juan;ZHANG Li-ping;SUN Ning;LI Xiao-jun(Institute of Clinical Laboratory Science,Jingling Hospital,Nanjing University School of Medicine/Nanjing General Hospital of Nanjing Military Region,PLA,Nanjing 210002,Jiangsu,China;Department of Clinical Laboratory,Nanjing Lishui District Hospital,Nanjing 211200,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2018年第9期972-976,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81470071)
江苏省临床医学科技专项(BL2014072)。
关键词
外泌体
细胞外囊泡
自身免疫病
系统性红斑狼疮
类风湿关节炎
exosomes
multivesicular bodies
autoimmune diseases
systemic lupus erythematosus
rheumatoid arthritis
