摘要
目的:探讨黄芪注射液联合丹参注射液治疗慢性阻塞性肺疾病的临床效果及对患者氧化应激水平的影响。方法:采用随机数字表法将137例慢性阻塞性肺疾病急性加重期(AECOPD)患者分为对照组68例和观察组69例。对照组给予常规治疗,观察组在对照组的基础上给予黄芪注射液联合丹参注射液治疗。观察两组治疗前后第1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1占FVC的百分比(FEV1/FVC%)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)和总抗氧化能力(T-AOC)水平,统计两组临床疗效。结果:观察组有效率显著高于对照组,差异有统计学意义(P<0.05)。两组治疗后FEVE1、FEV1/FVC水平与治疗前相比较均显著升高(P<0.05),且观察组与同期对照组相比较均显著升高(P<0.05)。两组治疗后SOD、GSH-Px、T-AOC水平与治疗前相比较均显著升高(P<0.05),且观察组与同期对照组相比较均显著升高(P<0.05);两组治疗后MDA水平与治疗前相比较均显著降低(P<0.05),且观察组与同期对照组相比较显著降低(P<0.05)。结论:黄芪注射液联合丹参注射液治疗AECOPD可改善患者肺功能,提高治疗效果,清除氧自由基和提高抗氧化能力可能是其重要作用机制。
Objective:To investigate the clinical effect of Astragalus injection combined with Salvia miltiorrhiza injection in the treatment of chronic obstructive pulmonary disease and its effect on the level of oxidative stress in patients.Methods:A total of 137 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)were divided into control group(68 cases)and observation group(69 cases)by random digital table.The control group was given routine treatment,and the observation group was treated with Astragalus injection combined with Salvia miltiorrhiza injection on the basis of the control group.The forced expiratory volume in first second(FEV1),the forced vital capacity(FVC),the percentage of FEV1 accounts for FVC(FEV1/FVC%),and the levels of serum superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)and total antioxidant capacity(T-AOC)before and after treatment of 2 groups were observed.The clinical effects of 2 groups were recorded.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05).The levels of FEV1 and FEV1/FVC in the 2 groups after treatment were significantly higher than those before treatment(P<0.05).And the increase of the observation group was significantly higher than that of the control group in the same period(P<0.05).The levels of SOD,GSH-Px and T-AOC in the 2 groups after treatment were significantly higher than those before treatment(P<0.05).And the increase of the observation group was significantly higher than that of the control group in the same period(P<0.05).The levels of MDA in the 2 groups after treatment were significantly lower than those before treatment(P<0.05).And the decrease of the observation group was significantly higher than that of the control group in the same period(P<0.05).Conclusion:Astragalus injection combined with Salvia miltiorrhiza injection in the treatment of AECOPD can improve lung function and improve treatment effect.Scavenging oxygen free radicals and improvi
作者
冯永海
李宏云
秦超
Feng Yonghai;Li Hongyun;Qin Chao(Department of Respiratory Medicine,the Fifth Affiliated Hospital of Zhengzhou University(Zhengzhou 450052))
出处
《陕西中医》
2018年第8期1048-1050,共3页
Shaanxi Journal of Traditional Chinese Medicine
关键词
肺疾病
慢性阻塞性/中西医结合疗法
黄芪注射液/治疗应用
丹参注射液/治疗应用
Pulmonary disease,chronic obstructive/integrated Chinese traditional and western medicine therapy
Huang Qi Zhu She Ye/therapeutic uses
Dan Shen Zhu She Ye/therapeutic uses
