摘要
目的探讨围绝经期甲状腺功能亢进(甲亢)对女性生活质量的影响因素。方法以2011年12月至2016年12月在成都市金牛区人民医院门诊就诊的153例围绝经期甲亢女性患者为研究对象,分为高分组(WHOQOL-BREF综合评分≥80分)与低分组(WHOQOL-BREF综合评分<80分),采用单因素χ~2检验与多因素Logistic回归方法对患者的生活质量影响因素进行分析。结果 153例患者的WHOQOL-BREF评分为24~108分,平均(79.4±10.5)分;其中高分组62例(40.5%),低分组91例(59.5%)。单因素分析显示,低分组血清游离甲状腺素(FT4)≥60pmol/L者(62.6%)明显高于高分组(33.9%),低分组婚姻状况为离异或丧偶者(31.9%)高于高分组(8.1%),低分组文化水平为初中及以下者(91.2%)高于高分组(75.8%),低分组家庭经济月收入<2 000元者(52.7%)高于高分组(32.3%),低分组家庭关系不和睦者(41.8%)高于高分组(17.7%),低分组长期食用豆制品者(56.0%)低于高分组(72.6%),低分组合并其他疾病者(84.6%)高于高分组(53.2%),差异均有统计学意义(P<0.05)。多因素分析显示,FT4值≥60pmol/L(OR=3.659,95%CI:1.246~9.231,P=0.002)、离异或丧偶(OR=2.144,95%CI:1.173~4.234,P=0.027)、家庭经济月收入<2 000元(OR=2.235,95%CI:1.023~5.776,P=0.033)、家庭关系不和睦(OR=1.813,95%CI:1.272~3.995,P=0.045)、合并其他疾病(OR=3.179,95%CI:1.142~8.579,P=0.011)为围绝经期甲亢女性患者生活质量低的主要危险因素,长期食用豆制品(OR=0.417,95%CI:0.102~0.876,P=0.024)为保护性因素,差异均有统计学意义(P<0.05)。结论围绝经期甲亢女性患者的生活质量水平较低,甲亢程度严重、离异或丧偶、家庭经济月收入<2 000元、家庭关系不和睦、合并其他疾病是其主要危险因素,长期食用豆制品是其保护性因素,应当加强此类患者甲亢及其他合并疾病的治疗控制,给予充分的家庭关怀与心理支持,指导增加豆制品饮食,以提高生活质量水平。
Objective To analyze the effect factors on quality of life of perimenopausal women with hyperthyroidism.Methods From December 2011 to December 2016,153 perimenopausal women with hyperthyroidism in our hospital were divided into high score group(WHOQOL-BREF score≥80)and low score group(WHOQOL-BREF score<80).The related effect factors of menopausal women with hyperthyroidism were analyzed with single factorχ2 test and multivariate Logistic method.Results The WHOQOL-BREF score of 153 patients was from 24 to 108 points,with an average of(79.4±10.5)points.There were 62 cases in high score group(40.5%)and 91 cases in low score group(59.5%).Univariate analysis showed that the rate of patients with FT4≥60 pmol/L in low score group was 62.6%,higher than 33.9%in high score group.The rate of divorced or widowed patients in low score group was 31.9%,higher than 8.1%in high score group(χ2=3.963,P=0.047).The rate of patients with culture of junior high school and below in low score group was 91.2%,higher than 75.8%in high score group(χ2=8.184,P=0.004).The rate of patients with family monthly income<2 000 yuan in low score group was 52.7%,higher than 32.3%in high score group(χ2=6.270,P=0.012).The rate of patients with family discord in low score group was 41.8%,higher than 17.7%in high score group(χ2=9.770,P=0.002).The rate of patients with long term consumption of soy products in low score group was 56.0%,lower than 72.6%in high score group(χ2=4.314,P=0.038).The rate of patients with other diseases in low score group was 84.6%,higher than 53.2%in high score group(χ2=17.982,P=0.000).These differences were statistically significant(P<0.05).Multivariate analysis showed that FT4≥60 pmol/L(OR=3.659,95%CI:1.246-9.231,P=0.002),divorced or widowed(OR=2.144,95%CI:1.173-4.234,P=0.027),family monthly income<2 000 yuan(OR=2.235,95%CI:1.023-5.776,P=0.033),family discord(OR=1.813,95%CI:1.272-3.995,P=0.045),combined with other diseases(OR=3.179,95%CI:1.142-8.579,P=0.011)were the main risk factors of low quality of life in perim
作者
王燕
李珂
WANG Yan;LI Ke(Department of Clinical Laboratory,Jinniu People′s Hospital,Chengdu,Sichuan 610036,China;Department of Clinical Laboratory,the Third People′s Hospital of Chengdu/the Affiliated Hospital of Southwest Jiaotong University,Chengdu,Sichuan 610031,China)
出处
《检验医学与临床》
CAS
2018年第13期1906-1909,共4页
Laboratory Medicine and Clinic
关键词
甲状腺功能亢进
围绝经期
生活质量
perimenopausal period
hyperthyroidism
quality of life
