摘要
目的:探讨系统性红斑狼疮(SLE)合并妊娠患者病情活动的影响因素和妊娠结局的关系。方法:回顾性研究188例SLE妊娠患者临床资料,分析影响SLE不良妊娠的相关因素。结果:188例共184次妊娠(4例失去随访)中足月产89例,早产19例,自然流产11例,死胎11例,中孕引产54例,胎儿丢失率高达41.3%;与存活胎儿相比,丢失胎儿与a PL、补体低下、狼疮活动、狼疮肾炎相关,差异具有统计学意义(P<0.05);孕中新发狼疮胎儿丢失率高达90%,其中狼疮活动、补体低下、狼疮肾炎等与既往狼疮相比更常见,差异有统计学意义(P<0.05)。结论:SLE妊娠患者妊娠结局较差。孕中新发狼疮、孕前SLE活动均与胎儿的丢失密切相关。
Objective:To investigate the relationship between the clinical outcome of pregnancy and disease activity of influential factors of systemic lupus erythematosus(SLE)patients.Methods:188 cases of SLE with pregnancy were investigated retrospectively in hospital,to analyze the related factors of adverse pregnancy of SLE patients.Results:Among all the 184 patients of 188 cases(4 cases lost follow-up),there are various kinds of cases,including full-term pregnancy in 89 cases,premature in 19 cases,and spontaneous abortion in 11 cases,stillbirth in 11 cases,pregnancy induced labor in 54 cases,and fetal loss rate as high as 41.3%.Compared with the surviving fetus,the differences in the loss of the fetus which was associated with aPL、low complement,lupus activity,lupus nephritis and the P value was<0.05,were statistically significant.The loss of fetal of new lupus was as high as 90%.Among them,lupus activity,low complement,lupus nephritis compared with previous lupus patients are more common.The differences,P values<0.05,were statistically significant,Conclusion:The clinical outcome of pregnancy with systemic lupus erythematosus is poor.The fetal of new lupus in pregnancy and the activity of the pre-pregnancy SLE are closely related to the loss of the fetus.
作者
刘珊珊
汪国生
金方圆
LIU Shan-shan;WANG Guo-sheng;JIN Fang-yuan(Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui)
出处
《安徽卫生职业技术学院学报》
2018年第3期116-118,共3页
Journal of Anhui Health Vocational & Technical College
关键词
系统性红斑狼疮
妊娠
妊娠结局
Systemic lupus erythematosus
Pregnancy
Outcome of pregnancy
