摘要
目的探讨系统性红斑狼疮(SLE)合并妊娠的临床特征及妊娠结局。方法对2016年10月至2018年7月蚌埠医学院第一附属医院收治的63例系统性红斑狼疮合并妊娠患者的临床资料进行回顾性分析。根据SLE疾病活动度评分将患者分为活动组(n=37)和非活动组(n=26),对其临床特点和妊娠结局进行总结分析。结果活动组和非活动组患者的妊娠丢失率(32.4%vs 3.8%)、早产率(54.1%vs 15.4%)、胎膜早破(27.0%vs 3.8%)、胎儿宫内生长受限(32.4%vs 7.7%)、活动性狼疮肾炎(37.8%vs 0)、皮肤损害(43.2%vs 11.5%)、低补体C3及C4发生率(48.6%vs 23.1%)、抗ds-DNA抗体滴度增高的发生率(59.5%vs 30.8%)比较,活动组均高于非活动组,差异均有统计学意义(P<0.05),而孕周[(35.04±2.90)周vs (38.10±0.76)周]、出生体质量[(2 586.15±743.27) g vs (3 230.00±395.63) g]和应用羟氯喹的比例(32.4%vs 73.1%)比较,活动组均低于非活动组,差异均有统计学意义(P<0.05)。结论 SLE合并妊娠患者易出现不良妊娠结局,非活动期选择性妊娠更易获得良好的妊娠结局。
Objective To investigate the clinical characteristics and pregnancy outcomes in women with systemic lupus erythematosus (SLE).Methods The clinical data of 63 pregnant women with SLE treated in the First Affiliated Hospital of Bengbu Medical College between October 2016 and July 2018 were collected and analyzed retrospectively.The 63 cases were divided into the flare group (n=37)and the non-flare group (n=26)according to the disease activity of SLE,and the clinical characteristics and pregnancy outcomes between the two groups were compared. Results The incidence of pregnancy loss,premature birth,premature rupture of membranes,fetal growth restriction, incidence of lupus nephritis,skin rash,low complement C3 and C4 incidence,increased rate of anti-ds-DNA antibodies of the flare group were 32.4%,54.1%,27.0%,32.4%,37.8%,43.2%,48.6%,59.5%,respectively,which were significantly higher than corresponding 3.8%,15.4%,3.8%,7.7%,0,11.5%,23.1%,30.8% of the non-flare group (all,P<0.05). The gestational age,birth weight,application ratio of hydroxychloroquine in the flare group were (35.04±2.90)weeks, (2586.15±743.27)g,32.4%,respectively,which were significantly lower than corresponding (38.10±0.76)weeks, (3230.00±395.63)g,73.1% in the non-flare group (all,P<0.05).Conclusion The pregnant women with systemic lupus erythematosus are high-risk patients for adverse pregnancy outcome.Selective pregnancy in non-flare period is more likely to achieve good pregnancy outcomes.
作者
王小月
张嵩
郭文静
陈琳洁
WANG Xiao-yue;ZHANG Song;GUO Wen-ring;CHEN Lin-jie(Department of Rheumatology and Immunology,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui,CHINA)
出处
《海南医学》
CAS
2018年第22期3159-3162,共4页
Hainan Medical Journal
关键词
妊娠
系统性红斑狼疮
妊娠结局
Pregnancy
Systemic lupus erythematosus (SLE)
Pregnancy outcome
