摘要
目的探讨血25-羟维生素D_3[25-(OH)D_3]、骨碱性磷酸酶(B-ALP)联合骨密度对小儿维生素D缺乏性佝偻病(佝偻病)的诊断价值。方法选取2014年1月至2016年6月宜城市人民医院收治的疑似佝偻病儿童107例作为研究对象,比较有无佝偻病组的血25-(OH)D_3、B-ALP、钙、磷水平和骨密度。并计算血25-(OH)D_3、B-ALP和骨密度及三者联合诊断佝偻病的诊断效能。结果 107例儿童中,检测出佝偻病患儿41例(38.32%);25-(OH)D_3+B-ALP+骨密度联合诊断佝偻病的灵敏度、准确度、阳性预测值(82.93%、93.46%、100.00%)均明显高于25-(OH)D_3(68.29%、85.98%、93.33%)、B-ALP(56.10%、78.50%、82.14%)和骨密度(51.22%、74.77%、75.00%)单独诊断。结论 25-(OH)D_3是诊断小儿维生素D缺乏性佝偻病的重要指标,联合B-ALP、骨密度可提高诊断的准确性。
Objective To investigate the diagnostic value of serum 25 hydroxyvitamin D3[25-(OH)D3],bone alkaline phosphatase(B-ALP)levels and bone mineral density index for vitamin D deficiency rickets(rickets)in children.Methods From Jan.2014 to Jun.2016,107 cases of suspected rickets in children in People′s Hospital of Yicheng City were selected as the research objects.The blood 25-(OH)D3,B-ALP,calcium,phosphorus levels and bone mineral density were compared between the group with and without rickets,and the diagnostic efficacies of 25-(OH)D3,B-ALP level and bone mineral density respectively and combined for rickets were calculated.Results Among the 107 cases,41 cases were detected rickets(38.32%).The sensitivity,specificity and accuracy and positive predictive value of 25-(OH)D3+B-ALP+bone density were 82.93%,93.46%and 100.00%,which were significantly higher than 25-(OH)D3(68.29%,85.98%,93.33%),B-ALP(56.10%,78.50%,82.14%)and bone density(51.22%,74.77%,75.00%)respectively.Conclusion 25-(OH)D3 is an important index for the diagnosis of rickets in children,and its combination with B-ALP,bone mineral density can improve the accuracy of diagnosis.
作者
欧丽黎
李吉华
OU Lili;LI Jihua(Department of Pediatrics,People′s Hospital of Yicheng City,Yicheng 441400,China)
出处
《医学综述》
2018年第7期1449-1452,共4页
Medical Recapitulate
