摘要
目的观察奥美拉唑联合气滞胃痛颗粒治疗反流性食管炎的临床疗效。方法选择2014年1月至2015年6月武汉市红十字会医院收治的反流性食管炎患者100例,采用随机数字法分为观察组和对照组,各50例。两组均给予常规治疗,对照组患者给予单用奥美拉唑治疗,每次20 mg,每日2次;观察组患者给予奥美拉唑(用法同对照组)联合气滞胃痛颗粒治疗,每次5 g,每日3次。两组疗程均为8周。比较两组患者治疗前后上食管括约肌(UES)静息压和下食管括约肌(LES)静息压、血清胃泌素及血浆胃动素、RDQ各症状评分、复发率及复发时食管黏膜内镜评分。结果观察组总有效率高于对照组[92.0%(46/50)比64.0%(32/50)](P<0.05)。治疗后观察组UES静息压及LES静息压高于对照组[(65±11)mm Hg(1 mm Hg=0.133 k Pa)比(54±8)mm Hg,(27±5)mm Hg比(23±4)mm Hg](P<0.01)。治疗后观察组胃泌素和胃动素水平高于对照组[(171±27)ng/L比(134±26)ng/L,(330±88)ng/L比(286±84)ng/L](P<0.01)。治疗后观察组胸痛、胃灼热、反食、反酸评分低于对照组[(0.81±0.22)分比(2.43±0.64)分,(1.14±0.32)分比(3.15±0.24)分,(1.21±0.27)分比(2.92±0.32)分,(1.15±0.34)分比(2.18±0.41)分](P<0.01)。治疗后观察组复发率及复发时食管黏膜内镜评分均低于对照组[24.0%(12/50)比46.0%(23/50),(1.4±0.4)分比(1.8±0.4)分](P<0.01)。结论奥美拉唑联合气滞胃痛颗粒治疗反流性食管炎,可明显提高胃动力,改善胃反流症状,降低复发率。
Objective To investigate effect of omeprazole combined with Qizhi Weitong granules on the levels of gastrin and motilin in patients with reflux esophagitis.Methods A total of 100 patients with reflux esophagitis in Wuhan Red Cross Hospital from Jan.2014 to Jun.2015 were randomly divided into an observation group and a control group.Both groups were given conventional treatment,and the control group was treated by omeprazole(20 mg/times,2 times/d),while the observation group was treated by omeprazole(usage same as the control group)combined with Qizhi Weitong granules(5 g/time,3 times/d).Upper esophageal sphincter(UES),lower esophageal sphincter(LES),gastrin,motilin,reflux diagnostic questionnaire(RDQ)scores,recurrence rate and esophageal mucosal endoscopy scores of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group[92.0%(46/50)vs 64.0%(32/50)](P<0.01).After treatment,UES resting pressure and LES resting pressure of the observation group were higher than those of the control group[(65±11)mmHg vs(54±8)mmHg,(27±5)mmHg vs(23±4)mmHg](P<0.01).After treatment,gastrin and motilin levels of the observation group were higher than those of the control group[(171±27)ng/L vs(134±26)ng/L,(330±88)ng/L vs(286±84)ng/L](P<0.01).After treatment,the scores of chest pain,heart burn,regurgitation and acid regurgitation in the observation group were lower than those in the control group[(0.81±0.22)score vs(2.43±0.64)score,(1.14±0.32)score vs(3.15±0.24)score,(1.21±0.27)score vs(2.92±0.32)score,(1.15±0.34)score vs(2.18±0.41)score](P<0.01).The recurrence rate and the endoscopic score of esophageal mucosa in the observation group after treatment were lower than those in the control group[24.0%(12/50)vs 46.0%(23/50),(1.4±0.4)score vs(1.8±0.4)score](P<0.01).Conclusion Omeprazole combined with Qizhi Weitong granules in treatment of reflux esophagitis can enhance gastric motility,improve gastric reflux symptoms,and reduce recurrence rate.
作者
任莉
黄健
REN Li;HUANG Jian(Department Four of Internal Medicine,Wuhan Red Cross Hospital,Wuhan 430021,China;Department Two of Surgery,Wuhan Medical Treatment Center,Wuhan 430021,China)
出处
《医学综述》
2018年第7期1444-1448,共5页
Medical Recapitulate
