期刊文献+

应用孟鲁司特钠治疗小儿喘息性支气管炎的临床疗效分析 被引量:4

Clinical analysis of montelukast in the treatment of asthmatic bronchitis in children
下载PDF
导出
摘要 目的分析应用孟鲁司特钠治疗小儿喘息性支气管炎的临床疗效。方法根据治疗方法将96例小儿喘息性支气管炎患儿分为46例对照组(常规治疗)和50例观察组(孟鲁司特钠治疗)。结果观察组临床总有效率分别92.00%高于对照组76.09%,观察组喘息消失时间(3.72±2.31)d、湿啰音消失时间(4.76±2.41)d、咳嗽消失时间(5.64±1.81)d、住院时间(6.73±2.41)d短于对照组(5.24±3.24)d、(6.98±2.54)d、(8.31±2.37)d、(9.36±3.15)d,观察组不良反应发生率6.0%,半年内复发率4.0%低于对照组15.2%、17.4%差异有统计学意义(P<0.05)。结论应用孟鲁司特钠治疗小儿喘息性支气管炎临床疗效确切,改善患儿临床症状显著。 Objective To analyze the clinical efficacy of montelukast in the treatment of asthmatic bronchitis in children.Methods According to the treatment method,96 children with asthmatic bronchitis were divided into 46 cases,the control group(routine treatment)and 50 cases of observation group(montelukast sodium treatment).Results The frequency of disappearance(3.72±2.31)d,the disappearance time of wet rales(4.76±2.41)d,the time of disappearance of cough(5.64±1.81)d,and the time of disappearance of cough were significantly higher than that of control group(76.09%),The time of hospitalization was(6.73±2.41)d shorter than that of the control group(5.24±3.24)d,(6.98±2.54)d,(8.31±2.37)d,(9.36±3.15)d;the incidence of adverse reactions in the observation group was 6.0%,and the recurrence rate was 4.0%lower than that in the control group at 15.2%,17.4%(P<0.05).Conclusion The clinical efficacy of montelukast in the treatment of children with asthmatic bronchitis is accurate,and the clinical symptoms of the patients are significantly improved.
作者 黎炳祥 王明义 方文 Li Bingxiang;Wang Mingyi;Fang Wen(Jiangmen City Xinhui Maternity and Children's Hospital,Jiangmen,Guangdong,529100,China)
出处 《当代医学》 2018年第13期14-17,共4页 Contemporary Medicine
关键词 小儿喘息性支气管炎 孟鲁司特钠 临床疗效 Children with asthmatic bronchitis Montelukast Clinical efficacy
  • 相关文献

参考文献10

二级参考文献70

  • 1胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社,2008:2138. 被引量:94
  • 2朱元钰 陈文彬.呼吸病学[M].北京:人民卫生出版社,2003.408. 被引量:141
  • 3陈新宙,黄荷,易飞,等.孟鲁司特钠联合小剂量阿奇霉素治疗小儿喘息性支气管炎临床观察[J].医学信息,.2013,12(22):87-88. 被引量:4
  • 4Oh JW, Shin SA, Loe HB. Urine Leukotirene E4 and eosinophil cationic protein in nasopharyngenal aspiration from young wheezy children [ J ]. Pediatr Allergy Immunol,2005 ,16 :416 - 421. 被引量:1
  • 5Tu L, XuX, Wan H, et al. Delivery of recombinant adeno - associ- ated - virus - mediated human tissue kallikrein for therapy of chro- nic renal failure in rats [ J ]. Hum GeneTher, 2008,19 ( 4 ) : 318 - 330. 被引量:1
  • 6Bisgaard H, Study G. On Montelukast and Respiratorg syneytial Vi- urs A Randomized trial of montelukast in respiratory syncytial virus postbronchiolitis [J]. Am J Respir Cift Care Med,2003,167:379 -383. 被引量:1
  • 7Weiss KA, Christiaansen AF, FultonRB, et al. Multiple CD4 + T cell subsets produce immunomodulatory IL - 10 during respiratory syncy viers infection [ J ]. J Immunol, 2011,187 ( 6 ) : 3145 - 3154. 被引量:1
  • 8Fleming DM,Elliot AJ.The management of acute bronchitis in children[J].Expert Opin Pharmacother,2014,8(4):415-426. 被引量:1
  • 9Stelmath I,Jerzynska J,Kuna P.A randomized,double-blind trial of the effect of treatment with montelukast on bronchial hyper responsiveness and serum eosinophilic cationic protein(ECP),soluble interleukin 2 receptor(SIL-2R),IL-4,and soluble intercellular adhesion molecule 1(s LCAM-1)in children with asthma[J].J Allergy Clin Immunol,2012,109(2):257-263. 被引量:1
  • 10Henderson WR,Tang LO,Chu SJ,et al.A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model[J].Am J Respir Crit Care Med,2012,165(1):108-116. 被引量:1

共引文献167

同被引文献23

引证文献4

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部