摘要
目的探究氟西汀对抑郁症患者认知记忆功能及相关事件电位P300(ERP-P300)的影响。方法将医院收治的72例抑郁症患者随机分为氟西汀组(36例)和对照组(36例),对照组给予神经内科常规治疗,氟西汀组在对照组基础上加用氟西汀治疗,比较两组治疗前和治疗后2、6 w时的汉密尔顿抑郁量表(HAMD)评分、韦氏记忆量表(WMS-RC)评分和ERPP300。结果治疗2、6 w后,两组HAMD评分均呈显著下降趋势(P<0.05),且氟西汀组均低于对照组(P<0.05);而两组WMS-RC评分均呈上升趋势(P<0.05),且氟西汀组均高于对照组(P<0.05);氟西汀组治疗2 w后的短时记忆和治疗6 w后的记忆商数(MQ)均明显高于同时间对照组(P<0.05);治疗2、6 w后,氟西汀组P2、N2、P3潜伏期呈进行性降低(P<0.05),而P2、N2波幅呈进行性升高(P<0.05),且与对照组有显著差异(P<0.05),而P3波幅无显著变化(P>0.05);对照组治疗期间ERP-P300总体变化不大(P>0.05)。结论氟西汀可有效改善抑郁症患者认知记忆功能,其作用机理可能与调节患者ERPP300有关。
Objective To explore the impacts of fluoxetine on cognition&memory functions of patients with depression and on event-related potential P300(ERP-P300).MeAods A total of 72 patients with depression admitted into our hospital were randomly divided into a fluoxetine group and a control group(n=36,respectively).Both groups received the conventional treatment of the Department of Neurology,and on the basis of this,the fluoxetine group received fluoxetine treatment additionally.Comparisons were made on the HAMD scores,WMS-RC scores and ERP-300 of the groups separately before the treatment and after two and six weeks'treatment.Results After Two and six weeks'treatment,the HAMD scores of both groups witnessed a significant decrease(P<0.05)and the scores of the fluoxetine group were lower than those of the control group.According to the comparison,the WMS-RC scores of both groups appeared to be increasing(P<0.05),and the scores of the fluoxetine group were higher than those of the control group.The patients'short-tenn memory after two weeks'fluoxetine treatment and the memory quotient(MQ)after six weeks'fluoxetine treatment were significantly higher than those of the control group during the same period(P<0.05).After two and six weeks'treatment,P2,N2 and P3 incubation periods of the fluoxetine group were shortened considerably(P<0.05)while P2 and N2 volatility showed a progressive rise(P<0.05),which was significantly different from the control group(P<0.05).No significant change in P3 volatility was observed(P>0.05).ERP-P300 of the control group did not show a major change during the treatment period(P>0.05).Conclusion Fluoxetine can effectively improve cognition&memory functions of the patients with depression,of which the mechanism of action may be related to the regulation of ERP-P300 of the patient.
作者
韩兴玲
王惠玲
Han Xingling;Wang Huiling(Mental Health Center of Hubei Province,Wuhan University,Wuhan,Hubei,430023,China;The Second Department of Psycholog,Wuhan Youfu Hospital,Wuhan,Hubei,430023,china;Mental Health Center of Renmin Hospital of Wuhan University,Wuhan,Hubei,430060,China)
出处
《西南国防医药》
CAS
2018年第4期334-337,共4页
Medical Journal of National Defending Forces in Southwest China
