摘要
目的探讨精神分裂症不同中医辨证分型患者的精神症状与认知功能特点及二者的相关性。方法选择新乡医学院第二附属医院2016年2月至2016年7月门诊及住院治疗的精神分裂症患者538例为研究对象,其中痰火内扰型143例,痰湿内阻型137例,阴虚火旺型43例,心脾两虚型41例,阳虚亏损型37例,气滞血瘀型126例,肝郁脾虚型11例。分别应用阳性与阴性症状量表(PANSS)和威斯康星卡片分类测验(WCST)对各型患者进行精神症状和认知功能评定,并分析精神分裂症患者的精神症状与认知功能的相关性。结果痰火内扰型、痰湿内阻型和阴虚火旺型患者阳性症状评分、正确应答数和完成分类数高于心脾两虚型、阳虚亏损型、气滞血瘀型和肝郁脾虚型患者(P<0.05);痰火内扰型、痰湿内阻型和阴虚火旺型患者阴性症状评分、持续错误数、错误应答数低于心脾两虚型、阳虚亏损型、气滞血瘀型和肝郁脾虚型患者(P<0.05)。痰火内扰型、痰湿内阻型和阴虚火旺型患者阳性症状和阴性症状评分、持续错误数、错误应答数、正确应答数和完成分类数比较差异无统计学意义(P>0.05);心脾两虚型、阳虚亏损型、气滞血瘀型和肝郁脾虚型患者阳性症状和阴性症状评分、持续错误数、错误应答数、正确应答数和完成分类数比较差异无统计学意义(P>0.05)。WCST中持续错误数、错误应答数、正确应答数和完成分类数与患者的发病年龄、病程及PANSS阳性症状评分无相关性(P>0.05),持续错误数、完成分类数与PANSS阴性症状评分呈负相关(r=-0.103、-0.184,P<0.05),正确应答数、完成分类数与受教育程度呈正相关(r=0.414、0.417,P<0.05)。结论不同中医证型精神分裂症患者的精神症状存在不同,其中痰火内扰型、痰湿内阻型和阴虚火旺型患者以阳性症状为主,心脾两虚型、肝郁脾虚型、阳虚亏损型和气滞血瘀型患者以阴性症
Objective To investigate the characteristics and associativity of psychotic symptoms and cognitive function in schizophrenic patients with different types of traditional Chinese medicine.Methods Five hundred and thirty-eight patients were selected in the Second Affiliated Hospital of Xinxiang Medical University from February 2016 to June 2016,among them,143 cases with pyrophlegm internal disturbance type,137 cases with phlegm resistance type,43 cases with yin deficiency with fire hyperactivity type,41 cases with heart-spleen deficiency type,37 cases with yang deficiency type,126 cases with qi-blood stagnation type and 11 cases with liver depression with qi stagnation type.The psychiatric symptoms and cognitive function of all the patients were assessed with the positive and negative syndrome scale(PANSS)and the Wisconsin card sorting test(WCST),and associativity of psychiatric symptom and cognitive function in schizophrenic patients was analyzed.Results Compared to the patients with heart-spleen deficiency type,liver depression with qi stagnation type,yang deficiency type and qi-blood stagnation type,the positive syndromes scores of PANSS,the number of correct responses and completed categories in the patients with pyrophlegm internal disturbance type,phlegm resistance type and yin deficiency with fire hyperactivity type were higher(P<0.01),and the negative syndromes scores of PANSS,the numbers of persistent errors and wrong answers were lower(P<0.01).There was no significant difference in the positive and negative syndromes scores of PANSS,the number of correct responses,completed categories,persistent errors and wrong answers among the pyrophlegm internal disturbance type,phlegm resistance type and yin deficiency with fire hyperactivity type(P>0.05).There was no significant difference in the positive and negative syndromes scores of PANSS,the number of correct responses,completed categories,persistent errors and wrong answers among the heart-spleen deficiency type,liver depression with qi stagnation type,yang d
作者
刘波
华婷婷
赵媛媛
王新友
张建宏
杨世昌
LIU Bo;HUA Ting-ting;ZHAO Yuan-yuan;WANG Xin-you;ZHANG Jian-hong;YANG Shi-chang(The Second Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)
出处
《新乡医学院学报》
CAS
2018年第4期298-302,共5页
Journal of Xinxiang Medical University
基金
河南省研究生教育教学改革研究与实践项目(编号:2017SJGLX078Y)
河南省卫生计生科技创新型人才工程专项资助项目(编号:201632-LJRC-062)
关键词
精神分裂症
中医辨证分型
阳性与阴性症状量表
认知功能
schizophrenia
different types of traditional Chinese medicine
positive and negative syndrome scale
cognitive function
