摘要
目的观察活性维生素D对早期糖尿病肾脏疾病患者炎性因子的影响。方法将符合诊断标准的86例患者随机分为试验组、对照组各43例。对照组采用常规治疗,试验组给予常规治疗+骨化三醇胶丸。两组疗程均为3个月。比较各组患者尿蛋白及炎性因子的变化。结果试验组治疗后,尿微量白蛋白、尿蛋白排泄率、尿蛋白定量均降低(P<0.01或P<0.05),超敏C反应蛋白、白介素6、肿瘤坏死因子-α水平较治疗前降低(P<0.05);对照组治疗前后各项指标比较差异无统计学意义(P>0.05)。结论活性维生素D可降低早期糖尿病肾脏疾病患者炎性因子水平,延缓糖尿病肾脏疾病的进展。
Objective:To observe the effect of active vitamin D on inflammatory factors in patients with early diabetic kidney diease(DKD).Method:Patients who met the standard of 86 patients were randomly divided into experiment group and control group with 43 cases in each group.The control group was treated with routine therapy,the experiment group was treated with routine therapy plus calcitriol soft capsules.All patients were observed for 3 months to compare the changes of urine protein and inflammatory factors levels before and after therapy.Result:The experiment group urinary microalbumin(mALB),urinary albumin excretion rate(UAER)and 24h urinary protein were all decreased(P<0.01 or P<0.05),and the levels of high sensitivity C reactive protein(hs-CRP),interleukin 6(IL-6)and tumor necrosis factor-alpha(TNF-α)were lower than those before treatment(P<0.05);They showed no significant difference in control group(P>0.05).Conclusion:Active vitamin D can reduce the level of inflammatory factors in patients with early DKD and delay the progress of DKD.
作者
焦东梅
JIAO Dongmei(The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,China)
出处
《泰山医学院学报》
CAS
2018年第4期391-393,共3页
Journal of Taishan Medical College
