摘要
目的探究艾司洛尔联合美托洛尔缓释片对急性ST段抬高心肌梗死疗效。方法选取2016年7月~2017年3月本院内心血管病内科就诊的STEMI患者80例,随机分为照组和研究组,各40例。对照组单纯用美托洛尔缓释片治疗;研究组用艾司洛尔联合美托洛尔缓释片治疗。比较两组患者治疗有效率;治疗前及治疗24 h心率、收缩压、舒张压变化;随访心因性死亡、新发心肌梗死、顽固心绞痛发生率;治疗前后心功能指标差异。结果研究组患者治疗有效率比对照组高(P<0.05);治疗前两组心率、收缩压、舒张压差异无统计学意义;治疗24 h研究组患者心率、收缩压、舒张压均优于对照组(P<0.05);研究组随访心因性死亡、新发心肌梗死、顽固心绞痛发生率比对照组低(P<0.05);治疗前两组心功能差异无统计学意义;治疗后研究组患者心功能指标均优于对照组(P<0.05)。结论艾司洛尔联合美托洛尔缓释片对急性ST段抬高心肌梗死疗效确切,可有效改善患者血压和心率,改善患者心功能,降低心因性死亡、新发心肌梗死、顽固心绞痛发生率,值得推广应用。
Objective To investigate the efficacy of esmolol combined with metoprolol sustained-release tablets in patients with acute ST elevation myocardial infarction.Methods From July 2016 to March 2017,80 STEMI patients admitted to our hospital for cardiovascular disease were randomly divided into control group and study group,40 in each.The control group was treated with metoprolol sustained-release tablets only.The study group was treated with esmolol combined with metoprolol sustained-release tablets.The treatment efficiency was compared between the two groups.The changes of heart rate,systolic blood pressure and diastolic blood pressure before treatment and 24 hours after treatment were observed.The incidences of cardiac death,new myocardial infarction and stubborn angina were followed up before and after treatment.Results The effective rate of treatment in study group was higher than that in control group(P<0.05).There was no significant difference in heart rate,systolic blood pressure and diastolic blood pressure before treatment in study group.Heart rate,systolic blood pressure and diastolic blood pressure in study group were better than those in control group(P<0.05).The follow-up of the study group was associated with cardiac death,the incidence of new myocardial infarction and stubborn angina was lower than that of the control group(P<0.05).There was no significant difference in the heart function between the two groups before treatment Patients with cardiac function indicators were better than the control group(P<0.05).Conclusion Esmolol combined with metoprolol sustained-release tablets is effective in acute ST-segment elevation myocardial infarction,which can effectively improve blood pressure and heart rate,improve cardiac function,reduce the incidence of cardiac death,new myocardial infarction,refractory angina The incidence,it is worth promoting application.
作者
万紫娟
张力
牛改红
Wan Zijuan;Zhang Li;Niu Gaihong(First People's Hospital of Jiujiang City,Physical examination,Jiujiang,Jiangxi,332000,China)
出处
《当代医学》
2018年第11期80-83,共4页
Contemporary Medicine
关键词
艾司洛尔
美托洛尔缓释片
急性ST段抬高心肌梗死
疗效
Esmolol
Metoprolol sustained-release tablets
Acute ST-segment elevation myocardial infarction
Efficacy
