摘要
目的探讨世居高原人群红细胞生理指标变化与冠心病(CAD)的相关性。方法入选2014年1月~2016年12月因胸痛并疑似冠心病于本院行冠状动脉造影检查,结果确诊为冠心病的患者618例为冠心病组,并随机选取同期行冠状动脉造影未提示明显异常的患者621例为对照组。检测记录相关临床资料并进行统计分析。结果两组患者性别、吸烟史、高血压病史、糖尿病史差异,以及D-二聚体(D-Dimer)、白细胞计数(WBC)、红细胞压积(HCT)、红细胞分布宽度(RDW)、总胆红素(TBIL)、间接胆红素(IBIL)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)结果具有统计学意义(P<0.05);Logistic回归分析显示,男性、吸烟、糖尿病、高血压、年龄、D-Dimer、RDW及LDL-C是冠心病的危险因素(P<0.05);TBIL和HDL-C是冠心病的保护因素(P<0.05);以海拔2 000 m、3 000 m作为分界点,将冠心病组分为较低海拔组、中等海拔组、较高海拔组,3组中男性、年龄、TBIL指标差异具有统计学意义(P<0.05)。结论男性、年龄、吸烟、糖尿病、高血压以及D-Dimer、RDW、LDL-C等指标的升高是世居高原人群冠心病发生发展的独立危险因素,而TBIL、HDL-C指标的升高是世居高原人群冠心病的保护因子,随着居住地海拔的升高,冠心病患者的年龄随之呈现年轻化趋向。
Objective To study the relationship between the changes of physiological indexes of red blood cells and the coronary artery disease(CAD)in the native of high altitude area.Methods From January 2014 to december 2016,618 patients with coronary heart disease(CHD)admitted to our hospital because of chest pain and suspected coronary artery disease were as CHD group.And 621 patients with normal coronary angiography were as control group.Check and record clinical data for statistical analysis.Results Gender,smoking history,hypertension history,diabetes history were all different in two groups(P<0.05).And D-Dimer,WBC,HCT,RDW,TBIL,IBIL,LDL-C,HDL-C were statistically significant different(P<0.05);Logistic regression analysis showed that male,smoking,diabetes,hypertension,age,D-Dimer,RDW,LDL-C were risk factors for coronary heart disease(P<0.05);TBIL,HDL-C were protective factors for coronary heart disease(P<0.05).CHD group were divided into low altitude group,middle altitude group,high altitude group according to altitude cut-off point of 2000 meters and 3000 meters.There were siginficant difference on percentage of male,age proportion and TBIL levels among three groups(P<0.05).Conclusion Male,age,smoking,diabetes,hypertension,D-Dimer,RDW and LDL-C are independent risk factors of coronary heart disease in native plateau population.TBIL and HDL-C are protective factors for coronary heart disease,with the increase of residence altitude,patients with coronary heart disease will show a trend of young age.
作者
邓勇
马晓峰
王红
曹建东
徐境苹
Deng Yong;Ma Xiaofeng;Wang Hong(Cardiovascular and Cerebrovascular Disease Hospital of Qinghai Province,Xining 810012,China)
出处
《中华保健医学杂志》
2018年第1期28-32,共5页
Chinese Journal of Health Care and Medicine
基金
青海省卫生计生青年课题(2016-wjqn-05)
关键词
高原地区
冠心病
红细胞
红细胞压积
红细胞分布宽度
Plateau area
Coronary heart disease
Red blood cell
Hematocrit
Red blood cell distribution width
