摘要
目的:探讨玻璃酸钠滴眼液对年龄相关性白内障超声乳化联合IOL植入术后眼部炎症反应和干眼症的影响。方法:回顾性分析我院2016-06/2017-07择期行超声乳化联合IOL植入术治疗的年龄相关性白内障患者200例200眼的临床资料,根据术后应用滴眼液的不同分为观察组和对照组(各100例)。观察组给予玻璃酸钠滴眼液,对照组给予妥布霉素地塞米松滴眼液。比较两组患者术前和术后第1、7、14d时泪膜破裂时间(break-up time,BUT)、角膜荧光素染色(fluorescein staining,FL)评分、房水蛋白浓度检查结果及眼表疾病指数(ocular surface disease index,OSDI)评分,并分析术后1、14d时结膜充血和睫状充血发生率。结果:术前和术后1d时两组患者组间OSDI评分比较,差异均无统计学意义(P>0.05);术后1、7、14d时两组患者OSDI评分均高于术前,差异均有统计学意义(P<0.05);且两组患者OSDI评分在术后1d达到最高后逐渐下降(P<0.05);观察组术后7、14d时OSDI评分均低于对照组,差异均有统计学意义(P<0.05)。术前、术后1d时两组患者组间BUT比较,差异均无统计学意义(P>0.05);术后1、7、14d时两组患者BUT均低于术前,差异均有统计学意义(P<0.05);且两组患者BUT在术后1d达到最低后逐渐升高(P<0.05);观察组术后7、14d时BUT均高于对照组,差异均有统计学意义(P<0.05)。术前、术后1d时两组患者组间FL比较,差异均无统计学意义(P>0.05);术后1、7、14d时两组患者FL与术前比较,差异均有统计学意义(P<0.05);且两组患者FL在术后1d达到最高后逐渐下降(P<0.05);观察组术后7、14d时FL均低于对照组,差异均有统计学意义(P<0.05)。两组患者术后1d结膜充血、睫状充血发生率比较,差异均无统计学意义(P>0.05);术后14d两组患者结膜充血、睫状充血发生率均低于术后1d,差异均有统计学意义(P<0.05),但对照组术后14d结膜充血、睫状充血发生率低于观察组,差异有统计学�
METHODS:The clinical data of age-related cataract patients treated with phacoemulsification combined with IOL implantation in 200 cases(200 eyes)of our hospital from June 2016 to July 2017 were retrospectively analyzed.According to the different postoperative application of eye drops they were divided into observation group and control group(100 cases each).The observation group was given sodium hyaluronate eye drops and the control group was given tobramycin dexamethasone eye drops.The results of BUT,FL,proteins concentration in aqueous and ocular surface disease index(OSDI)score were compared before and at the first day,the seventh day and the fourteenth day after the operation.And the incidence of conjunctival hyperemia and ciliary hyperemia was compared between 1d after surgery and 14d after surgery.RESULTS:There was no significant difference in OSDI scores between the two groups before and at 1d after surgery(P>0.05).The OSDI score of the two groups was higher than that before the operation on the first,the seventh and the fourteenth day after surgery(P<0.05).The OSDI score of the two groups decreased gradually after reaching the highest level on the first day after surgery(P<0.05).The OSDI scores of the observation group on the 7 and 14d after surgery were lower than those in the control group(P<0.05).There was no significant difference in the BUT between the two groups before and at 1d after surgery(P>0.05).The levels of BUT in the two groups were lower than those before operation on the first,the seventh and the fourteenth day after surgery(P<0.05).BUT levels in both groups increased gradually after reaching the lowest level on the first day(P<0.05),the levels of BUT in the observation group were higher than those in the control group on the 7 and 14d after operation(P<0.05).There was no significant difference in FL level between the two groups before and the first day after operation(P>0.05).The levels of FL in the two groups were different from those before operation(P<0.05)on the first,the seventh and
作者
何星光
龚兰兰
余才翰
Xing-Guang He;Lan-Lan Gong;Cai-Han Yu(Xianning Central Hospital,Xianning 437100,Hubei Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2018年第4期697-701,共5页
International Eye Science
关键词
玻璃酸钠滴眼液
年龄相关性白内障
超声乳化联合IOL植入术
眼部炎症反应
干眼症
sodium hyaluronate eye drops
age-related cataract
phacoemulsification combined with intraocular lenses implantation
ocular inflammation
dry eye
