摘要
目的:观察银杏叶注射剂液联合尼莫地平治疗轻中度血管性痴呆的临床疗效及血同型半胱氨酸(Hcy)和S100B蛋白的影响。方法:将98例轻中度血管性痴呆患者随机平均分为两组,对照组给予尼莫地平治疗,试验组给予银杏叶提取物联合尼莫地平治疗,其中尼莫地平的治疗方案同对照组。4周后采用简易智能状态检查量表(MMSE)、日常生活能力量表(ADL)及测定患者血Hcy和S100B蛋白的含量。结果:治疗4周后,试验组总有效率高于对照组,差异有统计学意义(P<0.05),试验组在MMSE、ADL评分方面较对照组均有显著改善,其差异有统计学意义(P<0.05)。治疗后两组的Hcy和S100B蛋白均明显降低,治疗组降低更明显,与对照组比较差异具有统计学意义(P<0.05)。结论:银杏叶注射液联合尼莫地平治疗血管性痴呆的临床疗效较好,可有效改善患者认知功能,并降低血Hcy和S100B的水平。
Objective:To investigate the effects of extract of ginkgo biloba leaf combined with nimodipine on homocysteine(Hcy),S100B and the treatment of vascular dementia(VD).Methods:98 cases with mild to moderate VD were randomly divided into control group and experimental group(each n=49).The control group was given nimodipine,while the patients in experimental group,on the basis of the above therapy in the control group,were additionally received intravenous ginkgo biloba leaf injection.The improvement of recognition ability,activities of daily life were grade 4 weeks later through mini-mental state examination(MMSE),activity of daily living(ADL).Also the levels of Hcy and S100B were detected before and after treatment.Results:After 4 weeks,the total effective rate of the experimental group was higher than control group,the difference was statistically significant(P<0.05).The scores of MMSE and ADL presented obviously superior figures and the difference was statistically significant(P<0.05).Moreover,the levels of Hcy and S100B decreased after treatment in both groups,but the Hcy and S100B in the treatmen group were lower than those in control group(P<0.05).Conclusion:For mild to moderate VD patients,the ginkgo biloba combined with nimodipine treatment can significantly improve the therapeutic effect and decrease the levels of Hcy and S100B.
作者
曹冰清
王涛
康涛
谢瑱
Cao Bingqing;Wang Tao;Kang Tao(The No.2 Department of Neurology,Shaanxi Province People's Hospital,Xi’an 710068)
出处
《陕西医学杂志》
CAS
2018年第3期379-381,385,共4页
Shaanxi Medical Journal
基金
陕西省社会发展科技攻关项目(2014K11-03-02-07)
