摘要
目的探讨支气管哮喘患儿血清心肌酶水平及免疫功能指标水平变化,分析其水平检测的临床价值。方法将100例支气管哮喘患儿纳入研究,分为急性发作组和缓解组,每组50例;选取同期健康儿童50例作为对照组。比较3组的血清心肌酶[天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)]及T淋巴细胞亚群(CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+)水平,并分析其与病情的相关性。结果支气管哮喘患儿发作期及缓解期的AST、LDH、CK、CK-MB、CD_4^+和CD_4^+/CD_8^+水平均明显高于对照组,且急性发作组水平明显高于缓解组,差异有统计学意义(P<0.05);急性发作组及缓解组的CD_8^+水平明显低于对照组,且急性发作组水平明显低于缓解组,差异有统计学意义(P<0.05)。支气管哮喘病情的严重程度与AST、LDH、CK、CK-MB、CD_4^+和CD_4^+/CD_8^+水平呈明显的正相关(P<0.05),与CD_8^+水平呈明显的负相关(P<0.05)。结论支气管哮喘患儿存在不同程度的心肌损伤及免疫功能异常,且随着病情的加重,患儿的心肌酶水平及免疫功能指标水平异常愈显著。
Objective To investigate the changes of serum myocardial enzyme and immune function in children with bronchial asthma,and to evaluate the clinical value of level detection.Methods 100 children with bronchial asthma were divided into acute attack group and remission group,50 cases in each group,50 healthy children were selected as control group;the level of serum myocardial enzyme(AST,LDH,CK,CK-MB)and T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)were compared between the 3 groups,and to analyze the correlation between levels and disease.Results The levels of AST,LDH,CK,CK-MB,CD4+and CD4+/CD8+in the children with asthma exacerbation and remission were significantly higher than those in the control group,and levels of acute attack group was significantly higher than the remission group,the difference was statistically significant(P<0.05).The level of CD8+in the acute attack group and remission group was significantly lower than that in the control group,and the level of the acute attack group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).Severity of bronchial asthma was significant positive correlation with AST,LDH,CK,CK-MB,CD4+and CD4+/CD8+(P<0.05),the severity of bronchial asthma was negatively correlated with the level of CD8+(P<0.05).Conclusion There were different degrees of myocardial damage and abnormal immune function in children with bronchial asthma.With the aggravation of the disease,the level of myocardial enzyme and immune function of children with asthma were more significantly abnormal.
作者
王艳
张华
关丽
王靳琎
周凤霞
WANG Yan;ZHANG Hua;GUAN Li;WANG Jinjin;ZHOU Fengxia(Department of Clinical Laboratory Dongfeng General Hospital Affiliated to Hubei Medical College,Shiyan,Hubei 442000,China;Experiment Center,Dongfeng General Hospital Affiliated to Hubei Medical College,Shiyan,Hubei 442000,China;Department of Pediatrics,Dongfeng General Hospital Affiliated to Hubei Medical College,Shiyan,Hubei 442000,China)
出处
《国际检验医学杂志》
CAS
2018年第3期316-318,321,共4页
International Journal of Laboratory Medicine
关键词
支气管哮喘
心肌酶
免疫功能
临床价值
bronchial asthma
myocardial enzyme
immune function
clinical value
