摘要
目的探讨尿道下裂的影响因素。方法选取2015年9月—2016年9月在郑州大学第三附属医院出生或就诊的尿道下裂患儿220例作为病例组,同期选取健康新生儿或非泌尿生殖系统疾病患儿220例作为对照组,采用多因素Logistic回归分析的方法,分析尿道下裂及Ⅰ、Ⅱ、Ⅲ、Ⅳ型尿道下裂的危险因素。结果多因素Logistic回归分析显示,尿道下裂的危险因素有不足月、胎儿生长受限、母亲居住地为农村、母亲妊娠年龄、母亲初次生产、母亲孕期吸烟与被动吸烟、母亲孕期服用孕激素、母亲孕期发生上呼吸道感染及发热、母亲孕早期高温暴露,保护因素有母亲孕早期补充蛋白质(P<0.05)。Ⅰ型尿道下裂的危险因素有母亲妊娠年龄,保护因素有母亲孕早期补充蛋白质(P<0.05)。Ⅱ型尿道下裂的危险因素有不足月、胎儿生长受限、母亲居住地为农村、母亲初次生产、母亲孕期吸烟与被动吸烟,保护因素有母亲孕早期补充蛋白质(P<0.05)。Ⅲ型尿道下裂的危险因素有不足月、胎儿生长受限、母亲居住地为农村、母亲初次生产、母亲孕期吸烟与被动吸烟,保护因素有母亲孕早期补充蛋白质(P<0.05)。Ⅳ型尿道下裂的危险因素有母亲孕期吸烟与被动吸烟、母亲孕期服用孕激素(P<0.05)。结论不同类型尿道下裂受多种因素影响,母亲孕期应避免不良生活习惯、少用激素类药物,孕早期补充蛋白质对预防胎儿发生尿道下裂有重要意义。
Objective To explore the influencing factors of hypospadias.Methods We enrolled 440 children who were delivered or received treatment in the Third Affiliated Hospital of Zhengzhou University from September 2015 to September 2016,including 220 with hypospadias(case group),and 220 healthy cases or with non-reproductive diseases(control group).Multivariate Logistic regression analysis was conducted to explore the overall risk factors for hypospadias,and risk factors for 4 different types of hypospadias.Results Multivariate Logistic regression analysis showed that preterm birth,fetal growth restriction,maternal rural residence,gestational age,primiparity,maternal smoking or passive smoking during pregnancy,progesterone treatment during pregnancy,prevalence of cold and fever during pregnancy,and exposure to high temperature during early pregnancy were the overall risk factors for neonatal hypospadias,while supplement of proteins during early pregnancy was its protective factor(P<0.05);the risk factors for typeⅠhypospadias were gestational age,and supplement of proteins during early pregnancy was its protective factor(P<0.05);the risk factors of typeⅡhypospadias were preterm birth,fetal growth restriction,maternal rural residence,primiparity,maternal smoking or passive smoking during pregnancy,and supplement of proteins during early pregnancy was its protective factor(P<0.05);preterm birth,fetal growth restriction,maternal rural residence,primiparity,and maternal smoking or passive smoking during pregnancy were the risk factors while supplement of proteins during early pregnancy was the protective factor for typeⅢhypospadias(P<0.05);the risk factors of typeⅣhypospadias were maternal smoking or passive smoking during pregnancy and progesterone treatment during pregnancy(P<0.05).Conclusion Neonatal hypospadias is affected by many factors.Mothers should avoid bad habits and steroid hormones during pregnancy.Early pregnancy,supplementation of protein is important for preventing the incidence of hypospadias in the f
作者
封全灵
王文娟
FENG Quan-ling;WANG Wen-juan(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国全科医学》
CAS
北大核心
2018年第3期289-295,共7页
Chinese General Practice
