摘要
背景:穿支皮瓣是临床修复皮肤软组织缺损的常用方法,choke vessels作为穿支血管之间相互沟通的桥梁,在跨区穿支皮瓣成活方面起着重要作用。目的:对穿支皮瓣中choke vessels新生过程的研究进展作一综述。方法:计算机检索1984至2017年Pub Med、中国知网和中国生物医学文献数据库等数据库收录的关于穿支皮瓣和穿支皮瓣中choke vessels新生的基础研究、临床报道和研究进展文献,英文检索词为"perforator flap,perforator vessels,choke vessels,choke zone",中文检索词为"穿支皮瓣,穿支血管,闭塞血管,choke血管"。结果与结论:最终纳入文献51篇进行总结综述。穿支皮瓣在临床广泛应用于修复各种原因导致的皮肤软组织缺损。相邻穿支血管之间通过choke vessels进行吻合,跨区穿支皮瓣成活与choke vessels的扩张新生密切相关。choke vessels新生与血管新生机制可能存在重叠,缺血缺氧预处理和炎性环境可能促进choke vessels新生。
BACKGROUND:Perforator flaps are used to repair skin and soft tissue defects.As a bridge between adjacent perforator vessels,choke vessels play an important role in the survival of extended perforator flap.OBJECTIVE:To review the research status and progress of the growth of choke vessels in perforator flaps.METHODS:A computer-based search of PubMed,CNKI and SinoMed databases was performed for the relevant literature concerning the research status and progress of the growth of choke vessels in perforator flaps published from 1984 to 2017.The keywords were“perforator flap,perforator vessels,choke vessels,choke zone”in English and Chinese,respectively.RESULTS AND CONCLUSION:Totally 51 articles were included for summary.Perforator flaps are extensively used to repair skin and soft tissue defects caused by various factors.Adjacent perforter vessels are connected by choke vessels,and the extended perforter flap survival is closely related to the dilatation and growth of choke vessels.Similarity may exist between the growth of choke vessel and angiogenesis.Hypoxia and ischemic preconditioning and inflammatory environment may promote the growth of choke vessels.
作者
李文波
张超
石杰
黄强
贾丁丁
高秋明
Li Wen-bo;Zhang Chao;Shi Jie;Huang Qiang;Jia Ding-ding;Gao Qiu-ming(Department of Orthopaedic Trauma,Orthopedics Center of Lanzhou General Hospital of Military Region of Chinese PLA,Lanzhou 730050,Gansu Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2018年第8期1261-1266,共6页
Chinese Journal of Tissue Engineering Research
基金
国家杰出青年科学基金项目(81600700)
甘肃省自然科学基金(1506RJZA298)~~
关键词
外科皮瓣
血管
新生血管化
生理性
组织工程
Surgical Flaps
Blood Vessels
Neovascularization
Physiologic
Tissue Engineering
