摘要
目的观察甲钴胺联合硫辛酸治疗糖尿病周围神经病变(DPN)的临床疗效。方法选择广西壮族自治区桂东人民医院2015-01-10—2017-05-31收治的DPN患者260例,采用随机数字表法分为对照组和观察组,每组130例。在常规治疗基础上,对照组患者采用甲钴胺治疗,观察组患者采用甲钴胺联合硫辛酸治疗。比较两组患者临床疗效,治疗前后密歇根糖尿病神经病变计分法(MDNS)评分、糖化血红蛋白及空腹血糖。结果观察组患者总有效率为83.85%,高于对照组的48.46%(P<0.05)。治疗前两组患者MDNS评分比较,差异无统计学意义(P>0.05),治疗后观察组患者MDNS评分低于对照组(P<0.05)。两组患者治疗前后糖化血红蛋白、空腹血糖比较,差异无统计学意义(P>0.05)。结论甲钴胺联合硫辛酸治疗DPN的临床疗效确切,可有效改善患者临床症状。
Objective To observe the clinical effect of mecobalamine combined with thioctic acid on diabetic peripheral neuropathy(DPN).Methods A total of260patients with DPN were selected in Guidong People's Hospital from2015-01-10to2017-05-31,and they were divided into control group and observation group according to random number table,each of130cases.Based on conventional treatment,patients of control group received mecobalamine,while patients of observation group received mecobalamine combined with thioctic acid.Clinical effect,MDNS score,HbA1c and FPG before and after treatment were compared between the two groups.Results Total effective rate of observation group was83.85%,was statistically significantly higher than that of control group of48.46%(P<0.05).No statistically significant differences of MDNS score was found between the two groups before treatment(P>0.05),while MDNS score of observation group was statistically significantly lower than that of control group after treatment(P<0.05).No statistically significant differences of HbA1c or FPG was found between the two groups before or after treatment(P>0.05).Conclusion Mecobalamine combined with thioctic acid has certain clinical effect in treating DPN,can effectively relieve the clinical symptoms.
作者
朱芳慧
ZHU Fang-hui(Guidong People's Hospital,Wuzhou 543000,China)
出处
《实用心脑肺血管病杂志》
2017年第B12期32-34,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
糖尿病神经病变
周围神经损伤
甲钴胺
硫辛酸
治疗结果
Diabetic neuropathies
Peripheral nerve injuries
Mecobalamine
Thioctic acid
Treatment outcome
