摘要
γδT细胞是T细胞的一个亚群,其TCR由γ链和δ链组成,为主要组织相容性复合体非限制性细胞。外周血γδT细胞大部分表达TCR Vγ9和Vδ2,能杀伤多种肿瘤细胞。本文将对γδT细胞的免疫学特性包括识别杀伤肿瘤细胞的机制及γδT细胞在肿瘤免疫治疗中的研究作一综述。
Gammadelta T cells are a small subset of T lymphocytes expressingγ-andδ-chain T cell receptors.Gammadelta T cells are main MHC-unrestrictive cells.The majority of human peripheral blood Gammadelta T cells express Vγ9 and Vδ2 T cell receptor and show cytotoxicity against a wide spectrum of tumor cells.Here,we review the immunological properties of gammadelta T cells including the recognition and killing mechanism against tumor cells,and summarize the results of gammadelta T cell-based cancer immunotherapy.
作者
肖凌
张钦
陈虎
张斌
Xiao Ling;Zhang Qin;Chen Hu;Zhang Bin(Department of Hematopoietic Stem Cell Transplantation,the 307th Hospital of Chinese People's Liberation Army,Beijing 100071,China)
出处
《中华细胞与干细胞杂志（电子版）》
2017年第1期54-58,共5页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
北京市科技计划课题(Z161100000516184)
关键词
T淋巴细胞
受体
抗原
T细胞
γ-δ
肿瘤
免疫疗法
T-lymphocytes
Receptors,antigen,T-cell,gamma-delta
Neoplasms
Immunotherapy
