摘要
21世纪,随着人类微生物基因组计划和人类肠道元基因组计划的开展,科学家们越来越关注存在于人体百万亿计的微生物,尤其是机体中最为复杂的胃肠道微生物。同时,肠道黏膜免疫学也是近年来备受关注的研究方向。肠道不仅是消化吸收的代谢场所也是重要的免疫器官,肠黏膜含有丰富的淋巴细胞,它们与肠道微生物相互作用,参与机体的免疫防御、免疫平衡和免疫监视。胃肠道微生态平衡发生紊乱会影响机体免疫应答反应,进而引起疾病的发生发展。本文从免疫学的角度来论述胃肠道微生物在肿瘤尤其是胃癌的发生和治疗中所扮演的角色。
In the 21 st century,with the unfolding of Human Microbiome Project and the Metagenomics of Human Intestinal Tract,scientists are increasingly concerned about hundreds of trillions of microbes existing in human body,especially the most complex gastrointestinal microbes.Meanwhile,intestinal mucosal immunology is also one of the most important research hotspots in recent years.Intestinal tract is not only a metabolic site for digestion and absorption,but also an important immune organ.There are abundant lymphocytes in intestinal mucosa,which interact with microbiota,and involve in immune defense,immune balance and immune surveillance together with microbiota.The imbalance of gastrointestinal microbiota will affect the immune response and cause the occurrence and development of diseases.In this article,the role of gastrointestinal microbes in the development and treatment of tumors,especially gastric cancer,was reviewed from the perspective of immunology.
出处
《中国微生态学杂志》
CAS
CSCD
2018年第2期216-221,239,共7页
Chinese Journal of Microecology
基金
山西省科技厅优秀人才科技创新项目(201705D211021)
关键词
胃肠道微生物
胃癌
肿瘤免疫治疗
幽门螺杆菌
黏膜免疫
Gastrointestinal microbiota
Gastric cancer
Immunotherapy
Helicobacter pylori
Mucosal im- munology
