摘要
一次性医用注射器中残留的有机物会通过注射药物进入人体,对健康构成危害。本研究利用电喷雾萃取电离-四极杆飞行时间质谱仪(EESI-Q TOF MS)快速检测和分析一次性注射器中的挥发性有机物残留。通过优化载气流量和毛细管电压,确定了最佳实验条件。在3种不同品牌的10mL一次性医用注射器中检测到多种挥发性物质。选取10个信号强度大于5 000的离子,利用碰撞诱导解离进行定性分析。对注射器中残留的环己酮进行半定量分析,检出限为0.13μg/L。实验还发现,环己酮在不同品牌的10mL注射器中的含量为0.39~0.64μg/L,在50mL注射器中的最大残留浓度达到2.52μg/L。结果表明,注射器体积越大,有机物残留量越高。该研究可为一次性注射器有机物残留检测和质量控制提供快速有效的技术手段。
Residual volatiles in disposable syringe can be injected into human body,which is considered as a potential health risk.Traditional method like gas chromatography(GC),liquid chromatography(LC)and gas chromatography mass spectrometry(GC/MS)are relative time consuming for detection.In this study,extractive electrospray ionization quadrupole time of flight mass spectrometry(EESI-Q TOF MS)was used for rapid analysis of volatiles in disposable syringe.The EESI ion source allows direct sampling of mixture,while the Q TOF promises an accurate measurement of m/z value as a high resolution mass spectrometry.The mass spectra were recorded in the mass range of m/z20-200in positive ion mode.To assist identification of compounds,collision induced dissociation(CID)analysis was performed with collision energy of(20±10)eV.Analytes were sampled via a T-tube,and sucked into the source chamber from the bypass through an80cm long,1.5mm inner diameter PTEF tube.The PTFE tube was heated to a constant temperature of100℃to avoid condensation which may lead to compound losses.The curtain gas was set at4.0L/min and200℃.Ion source parameters were optimized using cyclohexanone,and the optimal sampling flow rate and capillary voltage were set at3.5L/min and4000V,respectively.Various volatiles were detected from9syringes in10mL with3brands.Results showed that volatile compounds are similar in syringes with the same brands,but significantly different in species and content for syringes with different brands.Based on CID analysis,a total of10compounds with intensity over5000are identified including dimethylformamide(m/z74.0602),dimethyl sulfoxide(m/z79.0211),morpholine(m/z88.0765),cyclohexanone(m/z99.0802),ethylbenzene(m/z107.0859),4-viny-l-1-cyclohexene(m/z109.1016),diethyl urea(m/z117.1028),4-methy-l-4-vinyl-1,4-butanolide(m/z127.0756),benzothiazole(m/z136.0219)and dibutylformamide(m/z158.1545).According to previous studies,some of these volatile compounds are toxic and harmful to human body.Detection of syringes in different capacity in
作者
周文钊
陆燕
夏磊
黄超群
沈成银
储焰南
ZHOU Wenzhao;LU Yan;XIA Lei;HUANG Chaoqun;SHEN Chengyin;CHU Yannan(Anhui Province Key Laboratory of Medical Physics and Technology,Center of Medical Physics and Technology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei230031,China;University of Science and Technology of China,Hefei230026,China)
出处
《质谱学报》
EI
CAS
CSCD
北大核心
2018年第1期93-100,共8页
Journal of Chinese Mass Spectrometry Society
基金
国家重点研发计划项目(2016YFC0200200)资助
关键词
一次性注射器
挥发性有机物
电喷雾萃取电离质谱
disposable syringe
volatiles
extractive electrospray ionization mass spectrometry (EESI-MS)
