摘要
目的探讨地佐辛与盐酸右美托咪定预防小儿术后躁动的效果及安全性。方法择期行包皮套扎术患儿90例,随机分为地佐辛组、右美托咪定组和对照组,每组30例,均采用全身麻醉联合阴茎背神经阻滞麻醉。地佐辛组麻醉诱导后静脉泵注地佐辛0.1 mg·kg^(-1);右美托咪定组麻醉诱导后静脉泵注盐酸右美托咪定0.5μg·kg^(-1);对照组麻醉诱导后静脉泵注等剂量0.9%氯化钠注射液。观察患儿躁动发生率、手术后苏醒时间、手术中追加丙泊酚的量及手术结束后6 h内的不良反应。结果 3组患儿均顺利完成手术,手术后苏醒时间差异无统计学意义(P>0.05);地佐辛组、右美托咪定组和对照组手术后躁动发生率分别为3.33%,0.00%和46.67%(P<0.05),3组患儿术中均未追加丙泊酚,术后6 h内均未见明显不良反应。结论地佐辛与盐酸右美托咪定均可有效预防患儿术后躁动,无明显不良反应,临床可安全使用。
ObjectiveTo evaluate the effects and safety of dezocine and dexmedetomidine hydrochloride on the prevention of the pediatric postoperative agitation.MethodsA total of90pediatric patients undergoing prepuce cerclage were randomly divided into3groups(n=30):dezocine group(Group Dez),dexmedetomidine group(Group Dex)and control group(Group C),all groups were implemented general anesthesia combining with penile dorsal nerve block anesthesia.After induction of anesthesia,Group Dez and Group Dex were given0.1mg·kg-1of dezocine and0.5μg·kg-1of dexmedetomidine hydrochloride,respectively,Group C was given0.9%sodium chloride solution.The rate of pediatric agitation,the operating room,the recovery time,the amount of additional propofol during the operation and the adverse reaction incidence within6hours after the surgery(circulation and respiratory depression,drowsiness,headache,nausea and vomiting)were observed and recorded.ResultsAll groups have the surgery successfully done.There were no significantly difference among the three groups on the recovery time(P>0.05).The incidence of postoperative agitation was3.33%in Group Dez,0.00%in Group Dex,46.67%in Group C,respectively(P<0.05).All of the pediatrics in three groups were not given additional propofol.There was no obvious adverse reaction at the time of6hours after surgery.ConclusionDezocine and dexmedetomidine hydrochloride both can reduce the rate of postoperative agitation in pediatric patients and have no obvious side effects.Therefore,the clinical use of dezocine and dexmedetomidine hydrochloride are safe and effective.
作者
魏会霞
罗向红
WEI Huixia;LUO Xianghong(Department of Anesthesiology,Shiyan 442000,China;Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China)
出处
《医药导报》
CAS
北大核心
2018年第1期67-70,共4页
Herald of Medicine
关键词
地佐辛
右美托咪定
盐酸
躁动
麻醉
Dezocine
Dexmedetomidine,hydrochloride
Agitation
Anesthesia
