摘要
目的:探讨血清Fractalkine、Vaspin含量对冠心病病情的判断价值及其与心功能、心肌损伤程度的相关关系。方法:80例冠心病患者根据临床发作特点跟体征分为稳定型心绞痛组45例、不稳定型心绞痛组35例。另取同期在本院进行体检的心功能正常者50例作为正常对照组。检测各组研究对象的血清Fractalkine、Vaspin含量,超声心动图下心功能参数水平,血清心肌酶谱指标含量。进一步采用Pearson检验评估冠心病患者血清Fractalkine、Vaspin含量与病情严重程度的内在联系。结果:稳定性心绞痛组、不稳定性心绞痛组血清中Fractalkine的含量高于正常对照组,Vaspin的含量低于正常对照组,随心绞痛病情加重,血清Fractalkine含量上升、Vaspin含量下降(P<0.05)。稳定性心绞痛组、不稳定性心绞痛组的心功能参数LVEDD、LVEDV、LVESD、LVESV水平高于正常对照组,血清中心肌酶谱指标CK、CK-MB、LDH、AST、ALT的含量高于正常对照组,随心绞痛病情加重上述指标水平增加(P<0.05)。冠心病血清Fractalkine含量与心功能下降、心肌损伤程度呈正相关,Vaspin含量与心功能下降、心肌损伤程度呈负相关。结论:冠心病血清Fractalkine、Vaspin含量异常,且其异常程度与患者心功能、心肌损伤程度直接相关。
Objective:To study the value of serum Fractalkine and Vaspin contents for the diagnosis of coronary heart disease and the correlation with cardiac function and myocardial injury.Methods:80patients with coronary heart disease were divided into stable angina pectoris group(n=45)and unstable angina pectoris group(n=35)according to the clinical seizure characteristics and signs.50subjects with normal cardiac function who received physical examination in the hospital over the same period were selected as the normal control group.The serum Fractalkine and Vaspin contents,cardiac function parameter levels under ultrasonic cardiogram and serum myocardial enzyme spectrum contents of each group were detected.Pearson test was used to further assess the inner link of serum Fractalkine and Vaspin contents with disease severity in patients with coronary heart disease.Results:Serum Fractalkine contents of stable angina pectoris group and unstable angina pectoris group were higher than that of normal control group while Vaspin contents were lower than that of normal control group,and serum Fractalkine content increased while Vaspin content decreased with the aggravation of angina pectoris(P<0.05).Cardiac function parameters LVEDD,LVEDV,LVESD and LVESV levels of stable angina pectoris group and unstable angina pectoris group were higher than those of normal control group,serum myocardial enzyme spectrum indexes CK,CK-MB,LDH,AST and ALT contents were higher than those of normal control group,and the levels of above indexes increased with the aggravation of angina pectoris(P<0.05).Serum Fractalkine content in patients with coronary heart disease was positively correlated with the decrease of cardiac function and the degree of myocardial injury while Vaspin content was negatively correlated with the decrease of cardiac function and the degree of myocardial injury.Conclusion:Serum Fractalkine and Vaspin contents are abnormal in patients with coronary heart disease,and the abnormal degree is directly related to the cardiac function an
作者
陈曦
邓蔷
安娜
胡冬
庄利东
CHEN Xi;DENG Qiang;AN Na;HU Dong;ZHUANG Li-dong(Department of Laboratory Medicine, Mianyang Central Hospital in Sichuan Province, Mianyang City, Sichuan Province, 621000, China)
出处
《海南医学院学报》
CAS
2017年第19期2612-2615,共4页
Journal of Hainan Medical University
基金
四川省卫生计生委科技项目(17PJ380)~~
