摘要
目的观察孟鲁司特纳联合布地奈德治疗小儿咳嗽变异性哮喘的临床疗效。方法选择2014年7月至2015年6月河南省新野县人民医院儿科收治咳嗽变异性哮喘患儿140例,随机分为观察组与对照组,每组各70例。对照组采用布地奈德进行雾化治疗,观察组在对照组治疗基础上给予孟鲁司特纳片口服。两组均治疗12d。观察两组临床疗效及肺功能相关指标:1s用力呼气容积(FEV1)、最大呼气流量(PEF)和FEV1/FVC比值。结果观察组总有效率为98.6%(69/70),显著高于对照组77.1%(54/70),差异有统计学意义(P<0.05)。治疗前,观察组与对照组肺功能指标FEV1、PEF和FEV1/FVC比较差异无统计学意义(P>0.05);治疗后观察组FEV1、PEF和FEV1/FVC均显著高于对照组,差异有统计学意义(P<0.05)。结论采用孟鲁司特纳联合布地奈德治疗小儿咳嗽变异性哮喘,可有效提升治疗疗效,具有临床应用价值。
ObjectiveTo study the clinical effect of montelukast sodium and budesonide in children with cough variant asthma.MethodsA total of140children with cough variant asthma treated from July2014to June2015in our hospital were selected.The subjects were divided into two groups according to the different therapies,70cases in each group.Group B took budesonide;group A took the combined therapy of montelukast sodium and budesonide;the treatment lasted for12days.The clinical effect for two groups was analyzed,and observe the indexes related to pulmonary function:FEV1,PEF and FEV1/FVC.ResultsThe total effective rate of the observation group was98.6%(69/70),significantly higher than that of control group(77.1%,54/70),and there was statistical difference(P<0.05).Before treatment,there was no statistical difference in such pulmonary indexes as FEV1,PEF or FEV1/FVC between the observation and control group(P>0.05),but after treatment these indexes were significantly higher in the observation group than in the control group with statistical difference(P<0.05).ConclusionThe combined therapy of montelukast sodium and budesonide can efficiently improve the clinical effect in the treatment of children with cough variant asthma,which is worthy of clinical application.
作者
张迎霞
ZHANG Yingxia(Xinye People's Hospital of He'nan, Nanyang 473500,China)
出处
《中国中西医结合儿科学》
2017年第5期62-64,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
