摘要
目的探讨醋酸戈舍瑞林缓释植入剂对前列腺癌患者去势后PSA及P504S的影响。方法78例前列腺癌患者根据治疗方法分为2组，对照组患者行手术去势联合比卡鲁胺片治疗，治疗组在对照组的基础上给予醋酸戈舍瑞林缓释植入剂药物去势治疗。比较2组临床疗效、不良反应，治疗前后外周血指标变化、PSA及P504S水平。结果治疗组总有效率明显高于对照组。治疗后2组Hb及HCT水平均显著下降，且治疗组Hb及HCT水平明显低于对照组。与治疗前相比，2组治疗后1个月、3个月、6个月PSA及P504S水平均明显降低，且观察组均低于对照组（P＜0.05）。结论醋酸戈舍瑞林缓释植入剂疗效显著，改变外周血环境，可显著降低PSA及P504S水平。
Objective To investigate the effect of Goserelin Acetate Sustained-Release Depot on PSA and P504S in patients with prostate cancer after castration.Methods78cases of prostate cancer according to the treatment methods were divided into two groups,the control group was given surgical castration with Bicalutamide Tablets treatment,the treatment group was given goserelin acetate sustained-release depot on the basis of the control group.The adverse reactions,the peripheral blood indexes before and after treatment,PSA and P504S level were compared between the two groups.Resultse The total efficiency of treatment group was significantly higher than the control group.The two groups of Hb and HCT were significantly decreased after treatment,and the treatment group Hb and HCT were significantly lower than the control group.After treatment for1,3,6months in the two groups,PSA and P504S were significantly decreased than before treatment,and the treatment group was significantly lower than the control group(P<0.05).Conclusion Goserelin acetate sustained-release depot could change the situation of peripheral blood and significantly reduce the level of PSA and P504S with obvious efficacy.
作者
魏福奎
王耀锋
WEI Fu-kui;WANG Yao-feng(Department of Urology, Baoji Hospital Affiliated to Xi’an Medical University, Baoji 721006, China)
出处
《中国生化药物杂志》
CAS
2017年第12期217-218,共2页
Chinese Journal of Biochemical Pharmaceutics
