摘要
目的从循证医学角度荟萃分析负压封闭引流治疗糖尿病足溃疡的有效性和经济性,为临床决策与实践提供可靠性的证据.方法计算机检索2016年12月前全文发表在国内期刊杂志上的随机对照实验,筛选出符合纳入标准的文献并追踪相关参考文献,采用Cochrane协作网的文献质量标准对文献质量进行评价,并用Revman5.3软件进行Meta分析.结果共4篇文献符合纳入标准但总体质量为中等,负压封闭引流有利于缩短患者伤口愈合时间,合并效应量WMD=-16.95,95%CI为[-17.59,-16.31],P<0.00001,但患者伤口愈合时间的漏斗图圆点不对称,考虑存在发表性偏倚.结论负压封闭引流治疗糖尿病足溃疡的临床疗效优于其他治疗方法,但由于一定偏倚因素的影响,研究结果未来仍有待于更高质量证据的支持.
Objective To quantitatively analyze the effectiveness and expense of VSD in diabetic foot ulcerand provide the reliable evidence for clinical decision and practice bu using the Evidence-Based Medicine methods.Methods We searched randomized controlled trials that advertised in magazines or journals of china that beforeDecember of2016in CNKI,CBM,VIP and WanFang Database,and selected articles that conformed toinclusion-standard and the references were also retrieved,and then evaluated the quality of the articles by thequality evaluation standard of Cochrane collaboration,meta-analysis was performed by software Revman5.3.Results Four articles were included and the general quality was moderate;meta-analysis showed that the effectand expense of VSD was superior to other interventions in the treatment of diabetic foot ulcer;but the unsymmetricalfunnel plot suggested the existence of publication bias.Conclusions In the treatment of diabetic foot ulcer,theeffect and expense of VSD is superior to other interventions,deserves to expand and apply in hospitals,but due tothe existence of publication bias,the meta-analysis results need more reliable evidences to support in the future.
作者
翁晓春
李春
周松兰
唐哲
彭葆坤
WENG Xiao-chun;LI Chun;ZHOU Song-lan;TANG Zhe;PENG Bao-kun(Dept. of Endocrinology,Yan’an Hospital Affiliated to Kunming Medical University,Yunnan 650051,China)
出处
《昆明医科大学学报》
CAS
2017年第4期80-83,共4页
Journal of Kunming Medical University
基金
云南省自然科学基金资助项目(2013FZ284)
关键词
负压引流
糖尿病足
溃疡
META分析
Vacuumsealing drainage
Diabetic foot
Ulcer
Meta-analysis
