摘要
目的探讨血清胰岛素样生长因子-I(IGF-I)和胰岛素样生长因子结合蛋白(IGFPB-3)表达水平检测在脑肿瘤中的应用价值。方法采用化学发光法检测几种脑肿瘤患者血清IGF-I和IGFPB-3水平,其中脑膜瘤16例、胶质瘤13例、GH分泌型脑垂体瘤32例、非GH分泌型脑垂体瘤40例和30例健康对照者。结果脑膜瘤组和GH分泌型脑垂体瘤组IGF-I和IGFPB-3血清水平均高于健康对照组(均P<0.05);GH分泌型脑垂体瘤组IGF-I和IGFPB-3血清水平均高于非GH分泌型脑垂体瘤;GH分泌型脑垂体瘤血清IGF-I水平以术前高于术后(均P<0.05)。结论 IGF-I和IGFPB-3在许多脑肿瘤患者血清中表达水平升高,可辅助诊断某些脑部肿瘤;IGF-I、IGFPB-3在分泌型和非分泌型脑垂体瘤中的表达有明显差异,因此可以鉴别诊断脑垂体瘤的类型;分泌型脑垂体瘤术前IGF-I和IGFPB-3明显高于术后,可以通过监测其术后下降速度和程度来判断手术效果及患者恢复情况。
Objective To investigate the value of detecting the expression serum levels of insulin-like growth factor-I(IGF-I)and insulin-like growth factor binding protein-3(IGFBP-3)in patients with brain tumor.Methods Serum levels of IGF-I and IGFPB-3were detected by chemiluminescence in several patients with brain tumor,Of which16cases of meningioma,13cases of glioma,32cases of GH secreting pituitary adenoma,40cases of non-GH secreting pituitary tumors and30healthy controls.Results The serum level of IGF-I and IGFPB-3in group of meningiomas and GH secreting pituitary adenoma were higher than that in the healthy control group(P<0.05);The serum level of IGF-I and IGFPB-3in GH secreting pituitary tumors were higher than that in non-GH secreting pituitary adenoma;The serum level of IGF-I in GH secreting pituitary tumors preoperative were higher than that after surgery(P<0.05).Conclusion(1)The serum level of IGF-I and IGFPB-3increased in many patients with brain tumors,detecting their level can assist the diagnosis of certain brain tumors;(2)The serum level of IGF-I and IGFPB-3was significantly different in secreted and non-secreting pituitary tumors,which can take differential diagnosis on different type of pituitary tumor;(3)The serum level of IGF-I and IGFPB-3in GH secreting pituitary tumors preoperative were significantly higher than that after surgery,which can monitor the effect of surgery and observe patient recovery situation by detecting the speed and extent of IGF-I decline after surgery.
作者
章菊
叶书来
董行
张昌龙
周倩
ZHANG Ju;YE Shu-lai;DONG Hang(The Clinical Laboratory of South Department of Anhui Provincial Hospital 230001)
出处
《临床输血与检验》
CAS
2017年第5期475-478,共4页
Journal of Clinical Transfusion and Laboratory Medicine
