摘要
目的探讨人类免疫缺陷病毒(HIV)感染者/获得性免疫缺陷综合征(AIDS)患者HIV感染、乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)合并感染情况。方法回顾性分析首都医科大学附属北京佑安医院2009年8月至2014年3月收治的152例住院HIV/AIDS患者的临床资料,另外,选取同期20例健康体检者的检测结果,对CD4+T淋巴细胞绝对数、血常规、血生化肝功能、凝血项相关指标等进行统计学分析。结果 152例住院HIV/AIDS患者中,HIV感染者80例,HIV/HBV合并感染者44例,HIV/HCV合并感染者23例,HIV/HBV/HCV合并感染者5例。各感染组CD4+T低于参考区间者139例(91.4%),各感染组患者CD4+T水平较对照组差异均具有统计学意义(P均<0.001)。各感染组患者的贫血发生率为59%~65%。各感染组患者血红蛋白(HGB)、红细胞(RBC)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)以及肌酐(Cr)水平较对照组差异均具有统计学意义(P均<0.05)。HIV/HBV合并感染组患者凝血酶原时间(PT)和凝血酶原国际标准化比率(INR)均高于HIV感染组和健康对照组,组间差异均具有统计学意义(P均<0.05)。结论入院HIV/AIDS患者伴随HBV、HCV合并二重或多重感染情况严重,合并感染易造成贫血的发生、肝功能损伤及凝血功能下降。
Objective To investigate the co-infection situation of patients with human immunodeficiency virus(HIV)infection or with acquired immune deficiency syndrome(AIDS)complicated with hepatitis B virus(HBV)or/and hepatitis C virus(HCV)infection.Methods The clinical data of152hospitalized patients with HIV/AIDS from August2009to March2014from Infection Center of Beijing Youan Hospita,Capital Medical University were analyzed,retrospectively,meanwhile,the clinical data of20healthy subjects were selected.The absolute logarithm of CD4+T lymphocyte,blood routine,blood biochemical liver function,and coagulation index were analyzed,respectively.Results Among the152hospitalized patients with HIV/AIDS,80cases with HIV infection,44cases with HIV/HBV co-infection,23cases with HIV/HCV co-infection,and5cases with HIV/HBV/HCV co-infection.There were139(91.4%)cases with CD4+T lower than the reference interval in all the infection groups,compared with the control group,with significant differeces(F=29.343,P<0.001).The incidence rates of anemia in all the infection group was59%-65%.Compared with the control group,the levels of hemoglobin(HGB),red blood cell(RBC),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB)and creatinine(Cr)of patients in the infection groups were significantly different(all P<0.05).The levels of prothrombin time(PT)and thrombin officially standardized ratio(INR)of patients in HIV/HBV co-infection group were significantly higher than those in HIV infection group and healthy control group(all P<0.05).Conclusions HIV/AIDS patients complicated with HBV and HCV double or multiple infection was severe,this infection could easily lead to the occurrence of anemia,liver injury and coagulation function decreased.
作者
绳波
徐萌
李岚
杨籽翾
计云霞
王蕊
吴昊
崔红权
Sheng Bo;Xu Meng;Li Lan;Yang Zixuan;Ji Yunxia;Wang Rui;Wu Hao;Cui Hongquan(Department of Clinical Laboratory, Beijing Jiangong Hospital, Beijing 100054, China;Infection Center, Beijing Youan Hospita Infection Center, Capital Medical University, Beijing 100069, China)
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2017年第4期377-381,共5页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
