摘要
目的观察H型高血压患者血管内皮功能及脉搏波传导速度的变化。方法选择2015年9月~2015年12月于阳江市人民医院收治的入院诊断为原发性高血压患者250例,其中男性124例,女性126例。根据入院同型半胱氨酸(Hcy)水平将患者分为H型高血压组200例(Hcy≥10μmol/L)与对照组50例(Hcy<10μmol/L)。入组所有患者在入院第2 d完善以下检验指标,脉搏波传导速度(PWV);血流介导的血管舒张反应(FMD)、硝酸甘油介导的血管舒张反应(NMD);高敏C反应蛋白(hs-CRP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血糖(GLU)、丙氨酸转氨酶(ALT)、肌酐(Cr)。比较两组患者各检验指标有无差异,并将H型高血压组患者Hcy水平与hs-CRP、FMD、NMD、PWV水平进行相关性分析。结果与对照组相比,H型高血压组患者ALT、CR、GLU、TC、LDL无明显差异(P>0.05),hs-CRP、PWV水平明显升高(P<0.05),FMD、NMD降低(P<0.05)。相关性分析结果表明Hcy与ba-PWV呈正相关(P<0.05),与FMD、NMD呈负相关(P<0.05),Hcy与hs-CRP无明显相关性(P>0.05)。结论与普通原发性高血压相比,H型高血压患者血管内皮功能损害更严重,PWV水平更高,且这种变化随着Hcy的升高更加明显。
Objective To investigate vascular endothelial function and pulse wave velocity(PWV)in patients with H-type hypertension.Methods From2015.9to2015.12,250primary hypertension patients were included in this study.There were124males and126females.Based on level of homocysteine(Hcy),the patients were divided into control group(Hcy<10μmol/l)(50patients)and H-type hypertension group(Hcy≥10μmol/l)(200patients).PWV,flow-mediated dilatation(FMD),Nitroglycerin-mediated vasodilatation(NMD).high-sensitivity C-reactive protein(hs-CRP),total cholesterol(TC).low density lipoprotein cholesterol(LDL-C),blood glucose(GLU),alanine aminotransferase(ALT)and creatinine(Cr)were measured on the second day after admission.Results There was no difference of ALT,CR,GLU,TC,LDL between the two groups(P>0.05).The levels of hs-CRP and PWV in H-type hypertension group were significantly higher than those in control group(P<0.05).FMD and NMD were lower in H-type hypertension group than those in control group(P<0.05).The correlation analysis results showed that Hcy was positively correlated with ba-PWV(P<0.05),and negatively correlated with FMD and NMD(P<0.05).Hcy and hs-CRP had no significant correlation(P>0.05).Conclusion H-type hypertension patients have more serious vascular endothelial dysfunction and higher level of PWV,and this change is more obvious with the increase of Hcy.
作者
孟丽琴
利定建
傅应昌
陈进
胡业建
Meng Liqin;Li Dingjian;Fu Yingchang;Chen Jin;Hu Yejian(Department of Traditional Chinese Medicine, Yangjiang People's Hospital, Yangjiang 529500, China)
出处
《中国循证心血管医学杂志》
2017年第8期934-936,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
2015阳江市科技局课题(社发【2015】10)
