摘要
目的:分析长托宁极早期联合阿托品治疗急性有机磷中毒的临床疗效。方法:将2016年4月至2017年3月84例急性有机磷中毒患者按照数字表法分两组各42例。对照组采用单纯长托宁治疗,观察组则采用长托宁极早期联合阿托品治疗。比较两组急性有机磷中毒治疗总有效率;平均用药次数、中毒症状维持时间、胆碱酶活力恢复时间、平均住院时间;干预前后患者血清胆碱酯酶水平;中间期肌无力综合征等并发症发生率。结果:观察组急性有机磷中毒治疗总有效率高于对照组,P<0.05;观察组平均用药次数、中毒症状维持时间、胆碱酶活力恢复时间、平均住院时间短于对照组,P<0.05;干预前两组血清胆碱酯酶水平相近,P>0.05;干预后观察组血清胆碱酯酶水平优于对照组,P<0.05。观察组患者中间期肌无力综合征等并发症发生率显著低于对照组,P<0.05。结论:长托宁极早期联合阿托品治疗急性有机磷中毒的临床疗效确切,可有效改善患者病情,提高抢救成功率,缩短症状消失时间,促使血清胆碱酯酶恢复正常,减少用药的次数,减少严重并发症的发生,效果确切,值得推广。
Objective:To analyze the clinical curative effect of penehyclidine hydrochloride combined with atropine in the treatment of earlyacute organophosphorus poisoning.Methods:84cases of acute organophosphorus pesticide poisoning patients in April2016to March2017,were divided into two groups according to the digital table,with42cases in each.The control group was treated with penehyclidinehydrochloride,the observation group was treated by penehyclidine hydrochloride combined with atropine in the treatment of very early.Comparison of acute organophosphorus pesticide poisoning treatment efficiency;the average number of drug poisoning symptoms,durationof choline enzyme activity recovery time and hospitalization time of patients before and after intervention;serum cholinesterase levels;intermediate myasthenia syndrome and other complications were performed.Results:Acute organophosphorus pesticide poisoning treatmentefficiency in the observation group was higher than the control group,P<0.05;the observation group the average number of drug poisoningsymptoms,duration of choline enzyme activity recovery time,the average hospitalization time was shorter than the control group,P<0.05;before the intervention of serum cholinesterase levels in the two groups were similar,P>0.05;intervention to observe the serum cholinesteraselevel group than the control group,P<0.05.The incidence of complications such as intermediate stage myasthenia syndrome in the observationgroup was significantly lower than that in the control group,P<0.05.Conclusion:The clinical curative effect of penehyclidine hydrochloridecombined with atropine in the treatment of early acute organophosphate poisoning is effective.It can effectively improve the patients,improvethe success rate,shorten the time of symptoms disappear,the serum cholinesterase recovery,reduce the number of medication to reduce seriouscomplications,curative effect,worthy of promotion.
作者
罗亮
LUO Liang(Emergency ICU, Ganzhou People's Hospital of Jiangxi Province, Ganzhou Jiangxi 341000, China)
出处
《药品评价》
CAS
2017年第11期38-41,共4页
Drug Evaluation
基金
江西省赣州市科学技术局项目(基金编号
GZ2014ZSF177)
关键词
长托宁
极早期
阿托品
急性有机磷中毒
临床疗效
Long Horning
Very Early
Atropine
Acute Organophosphorus Pesticide Poisoning
Clinical Efficacy
