摘要
目的:分析和评价阿托品在临床上用于有机磷农药中毒的治疗效果。方法:收集了33篇以阿托品为试验组,盐酸戊乙奎醚(商品名长托宁)为对照组治疗有机磷农药中毒的文献,对结果进行荟萃(Meta)分析,评价指标采用优势比(OR)及其95%可信区间(95%CI),统计学分析采用RevMan 4.220软件。结果:阿托品与盐酸戊乙奎醚在治疗有机磷农药中毒时治愈率的差异存在统计学意义,其OR值为0.21,95%Cl为0.15～0.30。结论:相对于阿托品,盐酸戊乙奎醚对有机磷农药中毒的治疗更加有效。
Objective： To analyze and evaluate the therapeutic effectiveness of atropine in treatment of acute organophos phorus poisoning（AOPP）. Methods： Thirty-three articles about atropine（test group） and penehyclidine hydrochloride（control group） in treatment of AOPP were collected and studied by Meta analysis. Odds ratio（OR） and its 95% confidence interval（CI） were used as the measure parameters of the therapeutic effectiveness. The statistical analysis was performed by RevMan 4. 220 soflware. Results： The therapeutic effectiveness of atropine and penehyclidine hydrochloride in treatment of AOPP were signifi cantly different with OR 0.21 and 95 % CI 0. 15-0.30. Conclusion： Penehyclidine hydrochloride is more effective than atropine in treatment of AOPP.
出处
《药学服务与研究》
CAS
CSCD
2011年第6期456-458,共3页
Pharmaceutical Care and Research
基金
国家科技支撑计划(No.2009DAI76D030211)
