摘要
目的评价盐酸多奈哌齐治疗不同类型老年痴呆的临床疗效、安全性。方法选取我院2015年3月~2016年10月期间收治的126例老年痴呆患者作为研究对象,根据病理类型的不同将126例患者分为老年性痴呆组、血管性痴呆组、混合型痴呆组,均给予三组患者常规基础治疗+盐酸多奈哌齐治疗,对比三组患者治疗前、后的MMSE(建议精神状态评价量表)评分、ADL(日常生活能力)评分以及不良反应发生情况和疾病治疗总有效率。结果老年性痴呆组患者、混合型痴呆组患者治疗后的MMSE评分、ADL评分均明显升高,与治疗前比较差异有统计学意义(P<0.05),老年性痴呆组患者上述评分的变化幅度最大。血管性痴呆组患者治疗后的MMSE评分、ADL评分有所升高,与治疗前比较差异有统计学意义(P<0.05),但低于老年性痴呆组患者、混合型痴呆组(P<0.05)。三组药物不良反应发生率比较差异无统计学意义(P>0.05)。老年性痴呆组的疾病治疗总有效率为96.72%,高于血管性痴呆组的60.00%和混合型痴呆组的80.00%(P<0.05),血管性痴呆组、混合型痴呆组患者的疾病治疗总有效率比较差异有统计学意义(P<0.05)。结论盐酸多奈哌齐治疗老年性血管痴呆可获得显著疗效,治疗混合型痴呆可获得良好疗效,治疗血管性痴呆的疗效较差,但治疗不同类型老年痴呆均具有较高的安全性。
Objective To evaluate the clinical effect and safety of donepezil in the treatment of senile dementia.Methods126cases of senile dementia cured in our hospital from March2015to October2016were selected as thestudy object.According to the pathological type,the126patients were divided into senile dementia group,vasculardementia group and mixed dementia group.All the patients in the three groups were treated with routine basictreatment plus donepezil hydrochloride.Before and after treatment,MMSE(the proposed mental status evaluationscale),ADL(daily living ability)score,adverse reactions and the total effective rate of treatment of the three groupswere compared.Results The scores of MMSE and ADL of patients in senile dementia group and mixed dementiagroup were significantly increased.Compared with before treatm ent,there were significant differences(P<0.05).Thescores of the above scores were the greatest of the patients in senile dementia group.The scores of MMSE and ADLwere increased of patients in vascular dementia group,compared with those before treatment(P<0.05).But it waslower than that of senile dementia group and mixed dementia group(P<0.05).There was no significant differencein the incidence of adverse drug reactions between the three groups(P>0.05).The total effective rate of the diseasetreatment in the senile dementia group was96.72%,which was higher than60%in the vascular dementia group and80%in the mixed dementia group(P<0.05).The total effective rate of disease treatment in patients with vasculardementia and mixed dementia was also significantly different(P<0.05).Conclusion Donepezil hydrochlorideis effective in the treatment of senile vascular dementia.Good results can be achieved in the treatment of mixeddementia.The treatment of vascular dementia is less effective,but the treatment of different types of senile dementiahas high security.
作者
黄东伟
HUANG Dongwei(Huazhou People's Hospital, Huazhou 525100, China)
出处
《中国医药科学》
2017年第15期186-189,共4页
China Medicine And Pharmacy
