摘要
目的分析依达拉奉联合小牛血清去蛋白注射液对急性脑梗死患者血清超氧化物歧化酶(superoxide dismutase,SOD)、炎性因子水平及预后的影响,探讨该方案的临床价值。方法选取本院2013年5月至2016年5月收治的152例急性脑梗死患者为研究对象,按照随机数表法将入选患者分为观察组和对照组,每组各76例。所有患者均于常规治疗基础上静脉滴注依达拉奉,观察组患者加用小牛血清去蛋白注射液静脉滴注,两组患者均持续治疗3周。比较两组患者治疗前后血清SOD和炎性因子水平、美国国立卫生院卒中量表(National Institute of Health Stroke Scale,NIHSS)及日常生活活动能力(activity of daily living,ADL)评分变化,评价联合治疗方案的疗效和安全性。结果治疗后两组患者NIHSS评分、高敏C反应蛋白、肿瘤坏死因子-α、白介素-8水平较治疗前均显著降低(P<0.05),ADL评分和SOD水平较治疗前均显著升高(P<0.05),观察组患者上述指标变化较对照组更早且更显著(P<0.05)。观察组患者治疗总有效率显著高于对照组(P<0.05)。两组患者不良反应发生情况无显著差异(P>0.05)。结论依达拉奉联合小牛血清去蛋白注射液能够明显改善急性脑梗死患者血清SOD和炎性因子水平,降低神经缺损程度,提高患者生活自理能力,具有良好的疗效与安全性。
Objective To analyze the effect of Edaravone combined with Deproteinised calf blood injection on serum levels of superoxide dismutase(SOD),inflammatory factors and prognosis in patients with acute cerebral infarction,to investigate the clinical value of the scheme.Method152patients with acute cerebral infarction from May2013to May2016in our hospital were selected as the research objects,they were randomly divided into observation group and control group,each of76cases,all the patients were given intravenous infusion of Edaravone on the basis of conventional treatment,observation group patients added with Deproteinised calf blood injection intravenously,two groups were treated continuously for3weeks.Observed the two groups of patients before and after treatment of serum SOD,inflammatory factors and the National Institute of Health Stroke Scale(NIHSS),activity of daily living(ADL)score changes,evaluated of the efficacy and safety of combined treatment scheme.Result After treatment,the NIHSS score,high sensitivity C reactive protein,tumor necrosis factor-αand interleukin-8levels of the two groups were significantly lower than those before treatment(P<0.05),the scores of ADL and SOD were significantly higher than those before treatment(P<0.05),the changes of the indexes of observation group were earlier and more obvious than those in control group(P<0.05).The total effective rate of observation group was significantly higher than that of control group(P<0.05).There was no significant difference in adverse reactions between the two groups(χ2=0.187,P>0.05).Conclusion Edaravone combined with Deproteinised calf blood injection in patients with acute cerebral infarction can significantly improve the levels of serum SOD and inflammatory factors,reduce the degree of nerve defect and improve self-care ability,has good effect and safety,and is worthy of promotion.
作者
任蓓
张爱香
REN Bei;ZHANG Ai-xiang(Department of Internal Medicine-Neurology, Xi'an Fourth Hospital, Xi'an 710004, China)
出处
《中国医学前沿杂志（电子版）》
2017年第6期117-120,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
依达拉奉
小牛血清去蛋白注射液
急性脑梗死
超氧化物歧化酶
炎性因子
预后
Edaravone
Deproteinised calf blood injection
Acute Cerebral infarction
Superoxide dismutase
Inflammatory factor
Prognosis
