摘要
目的探讨血塞通注射液辅助治疗急性脑梗死的效果及对神经功能的影响。方法 90例急性脑梗死患者,按照随机数字法分为对照组与研究组,每组45例。对照组患者采用丁苯酞治疗,研究组患者给予血塞通注射液联合丁苯酞治疗。对两组患者临床效果、超氧化物歧化酶(SOD)水平、丙二醛(MDA)水平、美国国立卫生研究院卒中量表(NIHSS)评分及Barthel指数(BI)评分、不良反应进行比较。结果研究组患者临床总有效率为93.33%,显著优于对照组的73.33%,差异具有统计学意义(P<0.05)。干预前两组SOD、MDA水平及NIHSS、BI评分比较差异均无统计学意义(P>0.05);干预后两组SOD、MDA水平及NIHSS、BI评分均优于本组干预前,且研究组均优于对照组,差异均具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论在急性脑梗死患者治疗中选择血塞通注射液联合丁苯酞治疗疗效确切,可显著改善患者神经功能及日常生活活动能力,值得在临床上推广使用。
Objective To explore the effect of Xuesaitong injection in adjuvant treatment of acutecerebral infarction and its impact on neurological function.Methods A total of90acute cerebral infarctionpatients were divided by random number method into control group and research group,with45cases in eachgroup.The control group received butyphthalide for treatment,and the research group received Xuesaitonginjection combined with butyphthalide for treatment.Comparison were made on clinical effect,superoxidedismutase(SOD)level,malondialdehyde(MDA)level,National Institute of Health stroke scale(NIHSS)score,Barthel index(BI)score and adverse reactions in two groups.Results The research group had significantlybetter clinical total effective rate as93.33%than73.33%in the control group,and the difference had statisticalsignificance(P<0.05).Before intervention,both groups had no statistically significant difference in SOD,MDAlevel,NIHSS and BI score(P>0.05).After intervention,both groups had better SOD,MDA level,NIHSS and BIscore than before intervention,and the research group was better than the control group.Their difference hadstatistical significance(P<0.05).Both groups had no statistically significant difference in incidence of adversereactions(P>0.05).Conclusion Combination of Xuesaitong injection and butyphthalide shows affirmativecurative effect,and it can significantly improve nerve function and daily life activity of patients.So it is worthy ofclinical promotion and use.
作者
林岭海
陈莹
LIN Ling-hai;CHEN Ying(Department of Pharmacy, Huizhou City Central People’s Hospital, Huizhou 516001, China)
出处
《中国现代药物应用》
2017年第13期17-19,共3页
Chinese Journal of Modern Drug Application
关键词
血塞通注射液
丁苯酞
急性脑梗死
神经功能
Xuesaitong injection
Butyphthalide
Acute cerebral infarction
Neurological function
