摘要
目的脑梗死为常见脑血管疾病,病残率和病死率高,及时有效的治疗可明显改善预后,目前临床用药争议明显。本研究探讨前列地尔联合血塞通治疗脑梗死患者的临床效果,为临床选择提供依据。方法选取2015-01-01-2018-09-30安阳市第六人民医院收治的脑梗死患者作为研究对象,根据组间性别、年龄和病程保持均衡可比的原则选择观察组103例,对照组102例。比较两组患者疗效、神经功能、生活能力、血管内皮生长因子(vascular endothelial growth factor,VEGF)、C-反应蛋白(C-reactive protein,CRP)及血清铁蛋白(serum ferritin,SF)水平。结果观察组患者临床总有效率为94.2%,明显高于对照组的78.4%,两组比较差异有统计学意义,χ~2=10.771,P=0.001。治疗后观察组患者神经功能(NIH stroke scale,NIHSS)评分为(11.7±2.9)分,低于对照组的(14.9±3.0)分,两组比较差异有统计学意义,t=-7.764,P<0.001;治疗后随访3个月,观察组患者日常生活能力(activities of daily living,ADL)评分为(52.3±4.8)分,高于对照组的(42.6±5.3)分,两组比较差异有统计学意义,t=-13.874,P<0.001;治疗后观察组患者VEGF、CRP和SF水平分别为(181.7±16.9)pg/mL、(4.7±0.8)mg/mL和(129.1±12.7)ng/mL,均低于对照组的(203.9±18.0)pg/mL、(6.6±0.9)mg/mL和(145.9±14.3)ng/mL,两组比较差异均有统计学意义,均P<0.001。结论前列地尔联合血塞通可提高脑梗死治疗有效率,改善患者神经功能及日常生活能力,保护血管内皮功能,抑制炎症反应。
OBJECTIVE Cerebral infarction is a common cerebrovascular disease with high morbidity and mortality.The timely and effective treatment can significantly improve the prognosis.At present,the clinical drug controversy is obvious.This study explores the combination of alprostadil and Xuesaitong in the treatment of patients with cerebral infarction.The clinical effect provides a basis for clinical selection.METHODS The patients with cerebral infarction admitted to our hospital from January 1,2015 to September 30,2018 were selected as subjects.According to the principle of gender,age and duration of treatment,the observation group was selected in 103 cases and the control group in 102 cases.The efficacy,neurological function,viability and vascular endothelial growth factor(VEGF),C-reactive protein(CRP)and serum ferritin(SF)levels were compared between the two groups.RESULTS The total effective rate was 94.2%in the observation group,which was significantly higher than that in the control group(78.4%).The difference between the two groups was statistically significant(χ~2=10.771,P=0.001).The neurological function of the patients in the observation group after treatment(NIH stroke scale,NIHSS)score was(11.7±2.9),which was lower than the control group of(14.9±3.0).The difference between the two groups was statistically significant(t=-7.764,P<0.001).The patients in the observation group were followed up for 3 months after treatment.The activity of daily living(ADL)score was(52.3±4.8),which was higher than that of the control group(42.6±5.3).The difference between the two groups was statistically significant(t=-13.874,P<0.001).After treatment,levels of VEGF,CRP and SF in the observation group were(181.7±16.9)pg/ml,(4.7±0.8)mg/ml and(129.1±12.7)ng/ml,respectively,which were lower than those of the control group,(203.9±18.0)pg/ml,(6.6±0.9)mg/ml and(145.9±14.3)ng/ml.Differences were significant(all P<0.001).CONCLUSION Alprostadil combined with Xuesaitong can improve the efficiency of treatment of cerebral infarction
作者
王燕
郭学义
WANG Yan;GUO Xue-yi(Department of Neurology,The Sixth People's Hospital of Anyang,Anyang455000,P.R.China)
出处
《社区医学杂志》
2019年第19期1196-1199,共4页
Journal Of Community Medicine
关键词
前列地尔
血塞通
脑梗死
alprostadil
Xuesaitong
cerebral infarction
