摘要
目的:探讨口腔颌面部肿瘤患者治疗前后血浆纤维蛋白原(Fbg)和D-二聚体(D-D)含量的变化情况及其临床意义。方法:收治口腔颌面部良性肿瘤患者60例和口腔颌面部恶性肿瘤患者150例,比较两组患者治疗前后血浆Fbg与D-D含量变化情况,收集健康体检者50例。结果:治疗前,与良性肿瘤组相比,口腔颌面部恶性肿瘤初发未转移者Fbg、D-D水平升高,分别为(3.65±2.12)g/L、(0.82±0.23)mg/L,差异具有统计学意义(P<0.05);口腔颌面部肿瘤复发转移者Fbg、D-D水平显著高于良性肿瘤组,分别为(4.82±1.21)g/L、(2.42±0.21)mg/L,差异具有统计学意义(P<0.05)。治疗后,口腔颌面部肿瘤患者Fbg、D-D明显下降,差异具有统计学意义(P<0.05),不过仍显著高于正常水平。结论:口腔颌面部恶性肿瘤患者存在不同程度的凝血与纤溶系统异常,且随着治疗的继续,病情好转后患者血浆Fbg、D-D含量可作为判断与预测患者预后的两个重要指标。
Objective:To explore the changes of plasma fibrinogen(Fbg) and D-dimer(D-D) content in patients with oral and maxillofacial tumor before and after treatment and its clinical significance.Methods:60 patients with oral and maxillofacial benign tumor and 150 patients with oral and maxillofacial malignant tumor were selected.The changes of plasma Fbg and D-D content of two groups were compared before and after treatment.50 cases of healthy persons were collected.Results:Before treatment,compared with the benign tumor group,the Fbg、D-D levels of primary oral maxillofacial malignant tumor without metastasiswere rise,respectively (3.65±2.12)g/L,(0.82±0.23)mg/L,and the difference was statistically significant(P<0.05).The Fbg、D-Dlevels of recurrent oral maxillofacial malignant tumor with metastasis were significantly higher than those of the benign tumorgroup,respectively (4.82±1.21)g/L,(2.42±0.21)mg/L,and the difference was statistically significant(P<0.05).After treatment,theFbg and D-D levels of patients with oral and maxillofacial tumor were decreased significantly,and the difference was statistically significant(P<0.05).Abut still significantly higher than the normal level.Conclusion:Patients with oral and maxillofacial malignant tumors have different degrees of coagulation and fibrinolysis fibrinolytic system abnormalities,and with the continuation of the treatment,after the improvement of the condition,the plasma Fbg and D-D levels of patients can be used as two important indexes to judge and predict patient prognosis.
作者
韩远卓
杨梅
黄运动
Han Yuanzhuo;Yang Mei;Huang Yundong(Department of Stomatology,Weifang City Second People's Hospital of Shandong Province 261041)
出处
《中国社区医师》
2017年第3期113-114,116,共3页
Chinese Community Doctors
