摘要
目的:探讨宫颈癌患者手术前后血浆纤维蛋白原和D-二聚体水平的变化,为临床上预防血栓形成提供理论依据。方法:分别检测20例正常对照女性与20例宫颈癌患者手术前和手术后1天、3天、7天血浆纤维蛋白原和D-二聚体的含量。结果:宫颈癌患者血浆纤维蛋白原和D-二聚体的含量术前与对照组比较明显升高(P<0.05),术后1天血浆纤维蛋白原含量明显升高,与术前相比差异有统计学意义(P<0.05),D-二聚体水平均高于术前,其中术后1天、3天与术前相比,差异有统计学意义(P<0.01,P<0.05)。结论:宫颈癌患者存在血液高凝状态,处于血栓前状态,手术能促进宫颈癌患者凝血和纤溶水平的升高。血浆纤维蛋白原和D-二聚体的检测对临床上预防血栓形成有一定的指导意义。
Objective：To explore the changes of plasma fibrinogen and D-dimer levels before and after cervical cancer surgery,and provide a theoretical basis for preventing thrombopoiesis.Methods：The contents of plasma fibrinogen and D-dimer in 20 normal women and 20 patients with cervical cancer before surgery and at 1,3,7 days after surgery were detected respectively.Results：The contents of plasma fibrinogen and D-dimer in cervical cancer group before surgery were statistically significantly higher than those in control group（P0.05）;in cervical cancer group,there was statistically significant difference in plasma fibrinogen content between before surgery and at one day after surgery（P0.05）;the contents of D-dimer at 1,3,7 days after surgery were higher than that before surgery,and there was statistically significant difference between at 1 and 3 days after surgery and before surgery（P0.01,P0.05）.Conclusion：Hypercoagulable state（prethrombotic state） exists in patients with cervical cancer,surgery can promote coagulation and increase of fibrinolytic level of patients with cervical cancer;detecting plasma fibrinogen and D-dimer levels has a certain guiding significance for preventing thrombopoiesis.
出处
《中国妇幼保健》
CAS
北大核心
2013年第3期418-420,共3页
Maternal and Child Health Care of China
