摘要
目的:探讨血浆D-二聚体水平与宫颈癌治疗前后指标的变化情况及其临床意义。方法:对唐山弘慈医院2013年1月至2017年1月收治的40例宫颈癌患者的临床资料进行回顾性分析,将这些患者作为宫颈癌组,另选取唐山弘慈医院同期收治的40例宫颈良性病变患者作为良性组,选取唐山弘慈医院同期接收的40例健康体检人员为对照组,对三组人员术前的D-二聚体水平、阳性情况、宫颈癌组不同临床分期患者手术前后的血浆D-二聚体水平变化情况进行统计分析。结果:宫颈癌组患者术前的血浆D-二聚体水平显著高于良性组、对照组,差异具有统计学意义(P <0. 05)。而良性组患者术前的血浆D-二聚体水平又显著高于对照组,差异具有统计学意义(P <0. 05)。宫颈癌组患者术前的血浆D-二聚体阳性率50. 0%(20/40)显著高于良性组12. 5%(5/40)、对照组0(0/40),而良性组患者术前的血浆D-二聚体阳性率又显著高于对照组,差异具有统计学意义(P <0. 05)。宫颈癌组患者手术后的血浆D-二聚体水平显著低于手术前,差异具有统计学意义(P <0. 05)。其中Ⅰ期、Ⅱa期、Ⅱb期患者手术前后的血浆D-二聚体水平均逐渐提升,差异具有统计学意义(P <0. 05)。结论:血浆D-二聚体水平可能能够将有效依据提供给临床对宫颈癌临床分期及手术预后的判断。
Objective：To investigate the changes in plasma D-Dimer levels of patients with cervical cancer belween before and after treatment and its clinical significance. Methods：The clinical data of 40 patients with cervical cancer in Tangshan Hongci Hospital from January 2013 to January 2017 were retrospectively analyzed. These 40 patients were regarded as cervical cancer group. 40 patients with cervical benign lesions in the hospital were selected as benign group, and 40 healthy people in the hospital over the same period were selected as control group. The preoperative D-Dimer levels and D-Dimer positive rate among the three groups and changes in plasma D-Dimer levels between before and after surgery of patients with different clinical stages in the cervical cancer group were statistically analyzed. Results ： The D-Dimer level before surgery of the cervical cancer group was significantly higher than that of the benign group and control group, with statistically significant difference （ P 〈 0.05 ） , and the plasma D-Dimer level of the benign group was significantly higher than that of the control group, with statistically significant differenee （P 〈 0.05）. The plasma D-Dimer positive rate before surgery of the cervical cancer group （50.0%, 20/40） was significantly higher than that of the benign group （ 12.5%, 5/40） and control group （0%, 0/40）, and the D-Dimer positive rate of the benign group was significantly higher than that of the control group, with statistically significant difference （ P 〈 0.05 ）. The D-Dimer level before surgery of the cervical cancer group was significantly lower than that before surgery with statistically significant difference （ P 〈 0.05 ） , in which the plasma D-Dimer level of stage I, stage II A, stage II B patients were increased gradually with statistically significant difference （ P 〈 0.05 ）.Conclusions：Plasma D-Dimer level may be able to provide effective evidence for clinical judgement of staging and prognosis of cervical cancer.
作者
林琳
葛新苗
李冬雷
LIN Lin;GE Xinmiao;LI Dongleis(Department of Obstetrics and Gynecology,Tang-shan Hongci Hospital,Tangshan 063012,Hebei,China;Department of Obstetrics and Gynecology,Baoding the 2nd Central Hospital,Baoding 072750,Hebei,China;Department of Oncology,Baoding the 2nd Central Hospital,Baoding 072750,Hebei,China)
出处
《中国性科学》
2018年第9期29-31,共3页
Chinese Journal of Human Sexuality
基金
河北省2017年度医学科学研究重点课题计划项目(20171062)
关键词
血浆D-二聚体水平
宫颈癌
治疗前后变化情况
临床意义
Plasma D-Dimer level
Cervical cancer
Changes between before and after treatment
Clinical significance
