摘要
目的:探讨枸地氯雷他定对慢性荨麻疹IL-4、IL-18的影响。方法:收治慢性荨麻疹患者68例作为观察组。健康人68例作为对照组。观察组给予枸地氯雷他定治疗,比较两组治疗前、治疗第14天、治疗第28天血清IL-4、IL-18。结果:观察组治疗第28天总有效率明显高于治疗第14天,差异具有统计学意义(P<0.05)。观察组治疗前血清IL-18、IL-4高于对照组,差异具有统计学意义(P<0.05)。观察组治疗第28天血清IL-18低于治疗前,差异具有统计学意义(P<0.05)。结论:枸地氯雷他定治疗慢性荨麻疹疗效显著,通过调节血清IL-18起效。
Objective:To investigate the effect of desloratadine citrate disodium on IL-4,IL-18 in chronic urticaria.Methods:68cases of patients with chronic urticaria were as the observation group.68 cases of healthy persons were as the control group.Theobservation group were treated with desloratadine citrate disodium,the serum IL-4,IL-18 of the two groups before treatment,onfourteenth day and twenty-eighth day of treatment were compared.Results:The total effective rate of the observation group ontwenty-eighth day of treatment was significantly higher than that of fourteen days of treatment,and the difference was statisticallysignificant (P<0.05).Before treatment,the serum IL-18 and IL-4 in the observation group were higher than those in the controlgroup,the differences were statistically significant (P<0.05).The serum IL-18 of the observation group on twenty-eighth day oftreatment was lower than that before treatment,the difference was statistically significant(P<0.05).Conclusion:Desloratadinecitrate disodium in the treatment of chronic urticaria had remarkable curative effect,which worked by regulating serum IL-18.
作者
徐延峰
沈海莲
Xu Yanfeng;Shen Hailian(Wuwei Cancer Hospital,Gansu Province 733000)
出处
《中国社区医师》
2016年第29期43-43,45,共2页
Chinese Community Doctors
关键词
枸地氯雷他定
慢性荨麻疹
疗效
Desloratadine citrate disodium
Chronic urticaria
Curative effect
