摘要
目的:探讨血清人附睾分泌蛋白4(HE4)联合糖类抗原125(CA125)诊断卵巢癌的临床价值。方法:选择32例卵巢癌患者、35例卵巢良性肿瘤患者以及30例健康女性为研究对象,比较3组间血清HE4和CA125水平差异,计算血清HE4、CA125和HE4+CA125诊断卵巢癌患者的灵敏度、特异度和准确度。结果:卵巢良性肿瘤组和卵巢癌组患者血清HE4和CA125水平均明显高于对照组(P<0.05),且卵巢癌组患者血清HE4和CA125水平均明显高于卵巢良性肿瘤组(P<0.05)。血清HE4诊断卵巢癌的灵敏度、特异度、阳性预测值、阴性预测值和准确度均明显高于CA125,而联合检测HE4和CA125的灵敏度、特异度、阳性预测值、阴性预测值和准确度均明显高于任何一个单项检测(P<0.05)。结论:卵巢癌患者血清HE4和CA125水平明显升高,联合检测血清HE4和CA125可以提高诊断卵巢癌的准确性。
Objective:To explore the clinical value of serum human epididymis secretory protein 4(HE4) combined with carbohydrate antigen 125(CA125) in the diagnosis of ovarian cancer.Methods:32 patients with ovarian cancer,35 patients with benign ovarian tumor and 30 cases of healthy women were selected as the study objects.The differences of serum HE4 and CA125 level in 3 groups were compared.The sensitivity,specificity and accuracy of serum HE4、CA125 and HE4+CA125 in the diagnosis of ovarian cancer were calculated.Results:The serum HE4 and CA125 level of the benign ovarian tumor group and the ovarian cancer group were all significantly higher than those of the control group(P < 0.05),and serum HE4 and CA125 level of the ovarian cancer group were significantly higher than those of the benign ovarian tumor group(P < 0.05).The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of serum HE4 were significantly higher than those of CA125,and the sensitivity,specificity,positive predictive value,negative predictive value and accuracy of combined detection of HE4 and CA125 were significantly higher than those of any single detection(P < 0.05).Conclusion:The serum HE4 and CA125 level of ovarian cancer are elevated significantly,combined detection of serum HE4 and CA125 can improve the accuracy of the diagnosis of ovarian cancer.
作者
杨冬梅
Yang Dongmei(Maternal and Child Health Hospital of Anyang City,Henan Province 455000)
出处
《中国社区医师》
2016年第11期140-141,共2页
Chinese Community Doctors
关键词
卵巢癌
血清人附睾分泌蛋白4
糖类抗原125
Ovarian cancer
Serum human epididymis secretory protein 4
Carbohydrate antigen 125
