摘要
目的对广东省2001年急性弛缓性麻痹(AFP)病例进行病原流行病学分析。方法收集2001年AFP病例粪便标本,采用RDa和L20B细胞对标本进行病毒分离与鉴定,并对AFP病例的免疫史、性别、年龄、60d随访结果与病原学结果之间的关系进行了分析。结果 288例AFP病例均采集了粪便标本,分离到脊髓灰质炎病毒(PV)28株,阳性率为9.7％,均为疫苗株,其中Ⅱ型病毒(PVⅡ)15株,为优势株;分离到非脊灰肠道病毒(NPEV)21株,阳性率为7.3％。脊灰减毒口服活疫苗(OPC)“零”剂次免疫的AFP病例的PV分离率依次高于1-2次和完成3次以上(≥3)全程免疫者,达50.0％(9/18);22例无明确诊断的残留麻痹病例的PV分离率为27.3％,远高于其他病例,其中PVⅡ分离率最高,占22.7％(5/22)。结论2001年广东省未发现由脊灰野病毒引起的病例;PVⅡ可能是部分未完成全程免疫的AFP病例的致麻痹病因。
Objective To analyze pathogenic epidemiology of AFP (acute flaccid paralysis) cases in Guangdong in 2001. Virus isolation and identification of AFP cases feces specimen was conducted with RDa and L20B cells. Immunization history, sex, age and 60 days follow- up result of AFP cases were compared with the virus identified. Results The feces specimens of 288 AFP cases were collected, and 28 PV(poliovirus) strains were isolated, with 9.7% of the positive rate. All of them were vaccine strains, of which 15 strains were PVII ( predominant strains) . 21 NPEV isolated were obtained with 7.3% of positive rate. The PV isolated rate of AFP cases with zero - dose OPV immunization was 50.0% (9/18) and which was high than that of the cases with 1 -2 doses and ^3 doses. The PV isolation rate was 27.3% in the 22 cases of indeterminable residual paralysis, higher than that in other cases, and of which PVII isolation was the highest with the rate of 22.7%(5/22) .Conclusion No polio case caused by wild poliovirus was found in Guangdong province in 2001. The PVII might be the causes of part of AFP cases uncompleted OPV immunization.
出处
《华南预防医学》
2002年第5期15-18,共4页
South China Journal of Preventive Medicine
