摘要
目的:观察伍用纳络酮治疗中、重度新生儿HIE的疗效及治疗前后患儿血浆及脑脊液中β-内啡肽（β-EP）的变化。方法:将40例HIE患儿随机分为两组:纳络酮治疗组23例,对照组17例,两组除进行相同的常规治疗外,治疗组给纳络酮0.1mg/kg·d,以0.03～0.05mg/kg·h速度静滴,连续3天,观察患儿临床症状体征的变化并进行NBNA评分,治疗前后分别留取患儿血浆和脑脊液测定β-EP,并与20名正常儿对照。结果:治疗组患儿临床症状明显改善,NBNA评分明显提高,与对照组相比差异显著;两组患儿治疗前血浆和脑脊液中β-EP明显高于正常新生儿,治疗后较治疗前显著下降,但治疗组与对照组治疗前后血浆和脑脊液β-EP含量均无统计学差异。结论:伍用纳络酮治疗中重度HIE临床疗效显著。
To examine effects of Naloxone on neonates with hypoxic-ischemic encephalopathy (HIE) and to determine the changes ofB eta-endorphin(B-EP)level in these patients. Fourty patients with HIE were divided into naloxone-treated group(23)and control group(17) ,the former was given naloxone in three days, clinical symptoms and signs were observed. The concentrations of B-EP in both plasma and cerebrospinal fluid(CSF)were detected in these patients before and after naloxone treatment respectively and compared with 20 normal neonates. Results showed that Naloxone could relief the clinical symptoms and signs rapidly , improve NBNA score and shorten the disease course. The levels of B-EP in patients with HIE were significantly increased before treatment and recovered to nearly normal after treatment, but there was no difference between two groups. We concluded that Naloxone has some therapeutic effects on neonates with HIE.
出处
《新生儿科杂志》
2002年第5期196-198,206,共4页
The Journal of Neonatology
基金
国家九五攻关项目研究内容项目编号:96-904-06-04
