摘要
目的 探讨肺癌组织中MAGE 12mRNA的表达及其意义。方法 采用RT PCR技术 ,检测了MAGE 12在 5 0例临床病人肺癌标本中mRNA水平的表达。结果 5 0例临床肺癌标本中有 17例表达 (17 5 0 ,3 4% ) ,且肺鳞癌 (15 3 3 ,45 5 % )与肺腺癌 (2 17,11 8% )有显著差异 (P <0 0 5 )。结论 MAGE 12基因在肺癌有较高的表达率 ,基于MAGE
Objective To investigate the expression of MAGE 12 mRNA in lung cancer and its relationship with pathological types Methods The expression of MAGE 12 gene was detected in samples of 50 cases of clinical lung cancer with RT PCR The results were analyzed with their pathological types Results MAGE 12 expression was found in 17 samples (34%), and the positive rate was significantly different in squamous cell carcinomas (45 5%,15/33) and in adenocarcinoma (11 8%,2/17) Conclusion MAGE 12 mRNA is expressed in lung cancer in a high level, implying tumor vaccines based on MAGE 12 or its product may be contributive in the treatment of lung cancer
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2002年第10期1146-1148,共3页
Journal of Third Military Medical University
基金
国家重点基础研究发展规划资助项目 ("973"项目 ) ( 2 0 0 1CB510 0 0 1)
