摘要
目的 探讨 p5 3、CD3 4 、E 钙粘蛋白 (E cadherin)在膀胱移行细胞癌中的表达及判断膀胱癌预后的价值。 方法 采用免疫组化方法检测 4 6例膀胱移行细胞癌和 8例正常膀胱粘膜标本p5 3、CD3 4 、E cadherin的表达情况。 结果 4 6例膀胱癌标本中p5 3、E cadherin的异常表达率分别为2 1.7%和 4 5 .6 %。p5 3异常表达在表浅型膀胱癌为 9.1% ,浸润型为 33.3% ,差别有显著性意义 (P <0 .0 5 ) ;病理Ⅰ～Ⅱ级异常表达 7.1% ,Ⅲ级 4 4 .4 % ,差别有显著性意义 (P <0 .0 0 5 ) ;复发组异常表达89 % ,未复发组 15 % ,差别有显著性意义 (P <0 .0 0 5 )。E Cadherin的异常表达率在浅表型膀胱癌为77.3% ,浸润型为 33.3% ,差别有显著性意义 (P <0 .0 0 5 ) ;在Ⅰ、Ⅱ级膀胱癌为 71.4 % ,Ⅲ级为2 7.8% ,差别有显著性意义 (P <0 .0 0 5 ) ;在复发组与未复发组分别为 18.0 %和 6 1.0 % ,差别有显著性意义 (P <0 .0 1)。CD3 4 在膀胱癌中的异常表达率为 4 1.3% ,在不同分期分级及复发与未复发组之间的表达差别均无显著性意义。 结论 p5 3和E Cadherin的异常表达与膀胱癌的恶性程度及复发密切相关 。
Objective To study p53,CD 34 , E cadherin expression in bladder transitional cell carcinoma. Methods Immunohistochemical method was used to detect p53,CD 34 , E cadherin in 46 cases of bladder transitional cell carcinoma and 8 normal controls. Results Normal p53 and E cadherin expression was found in all the 8 normal bladder mucosa.Abnormal p53 and E cadherin expression were found in 10 and 21 cases of bladder cancer(21.7%,45.6%).Abnormal p53 and E cadherin expression were inversely correlated to grade,stage and high recurrence.CD 34 expression in bladder cancer differs from that in normal controls,but no prognostic value has been observed. Conclusions Abnormal expression of p53 and E cadherin is closely related to the malignant progression of bladder cancer.Detect of p53 and E cadherin expression is helpful in predicting the biological behavior of bladder transitional cell carcinoma.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2002年第10期601-603,共3页
Chinese Journal of Urology
