摘要
目的 :研究血管紧张素Ⅱ 1型受体拮抗剂 (AT1RA) -氯沙坦对链脲佐菌素 (STZ)大鼠肾小管间质血管内皮生长因子 (VEGF)和CD68表达的影响。方法 :用Wistar大鼠建立STZ诱导的糖尿病 (DM )模型 ,设正常对照组(C)、糖尿病组 (D)和糖尿病 +氯沙坦治疗组 (DA)。用免疫组化方法观察肾小管间质VEGF和CD68的变化。结果 :VEGF及CD68在DM大鼠肾小管间质部位较对照组显著升高 (P <0 .0 1)。DA组给予氯沙坦治疗可使VEGF及CD68在肾小管间质表达降低。VEGF与CD68在肾小管间质表达呈显著正相关。结论 :氯沙坦可降低糖尿病大鼠肾小管间质VEGF和CD68表达 。
Objective:To evaluate the effects of losartan on expressions of vascular endothelial growth factor(VEGF) and CD 68 in the tubulointerstitium of diabetic rats.Methods:Streptozotocin-induced diabetic Wistar rats were divided into the control group(C),diabetic group(D) and diabetic+losartan group(DA).The protein expressions of VEGF and CD 68 were determined by immunohistochemitry.Results: The protein expressions of VEGF and CD 68 were incrensed significantly in the tubulointerstitium of DM rats( P <0.01),compared with control group.The expressions of VEGF and CD 68 were decreased by losartan treatment in DA group.The expression of VEGF showed positive correlation( P <0.01)with CD 68 in the tubulointerstitium.Conclusion:Losartan can deciease the expressions of VEGF and CD 68 in the tubulointerstitium of diabetic rats and reduce the impairment of tubulointerstitium.
出处
《中国中西医结合肾病杂志》
2002年第9期504-506,515,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
