摘要
观察了心脉灵注射液对内毒素休克大鼠脑组织脂质过氧化系统指标超氧化物歧化酶 (SOD)和丙二醛(MDA)的影响。结果表明 :心脉灵注射液可稳定大鼠平均动脉血压 ,降低脑含水量和 6h死亡率 ,阻止或减少SOD下降 ,减少MDA的生成 ,具有良好的抗休克作用。提示心脉灵注射液可能通过抑制、减轻内毒素休克大鼠脑组织脂质过氧化作用 ,从而减轻休克时脑损伤的发生发展。
Effects of Xinmailing Injection (XI) on SOD and MDA, the two criteria for the lipid peroxidation in the cerebral tissue, were observed in the rats with endotoxic shock. The results showed that XI had good antishock effects, including stabilizing the mean arterial pressure, reducing the water content of cerebral tissue, lowering the 6 hour mortality, controlling or reducing the decrease in the level of SOD, and decreasing the production of MDA. The results suggest that XI may relieve cerebral injury caused by endotoxic shock through inhibiting or reducing the effects of lipid peroxidation in cerebral tissue.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2002年第5期17-19,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
高等学校博士学科点科研基金课题
