摘要
The allergens causing mango dermatitis have long been suspected to be alk(en)y l catechols and/or alk(en)yl resorcinols on the basis of observed cross-sensiti vity reactions to mango in patients known to be sensitive to poison ivy and oak (Toxicodendron spp.). Earlier, we reported the 3 resorcinol derivatives:heptade cadienylresorcinol (I), heptadecenylresorcinol (II) and pentadecylresorcinol (II I); collectively named ‘mangol’, as mango allergens. In this study, we extract ed the 1st 2 components (I and II) from the Philippine mango, adjusted them to 0 .05%concentration in petrolatum and patch tested the components on 2 subjects w ith mango dermatitis. Both subjects reacted to I. 1 subject also elicited a weak er positive reaction to II. To investigate the cross-reaction between mangol an d urushiol, we also patch tested the same subjects with urushiol. The subject sensitive to II reacted to urushiol. 6 subjects with a history of lacq uer contact dermatitis and positive reactions to urushiol were similarly patch t ested. 5 persons reacted to I. 2 subjects also exhibited a slower but positive r eaction to II. This is the 1st report in which heptadec(adi)enyl resorcinols kno wn to bepresent in man go have been shown to elicit positive patch test reaction s in mango-sensitive patients.
The allergens causing mango dermatitis have long been suspected to be alk(en)y l catechols and/or alk(en)yl resorcinols on the basis of observed cross-sensiti vity reactions to mango in patients known to be sensitive to poison ivy and oak (Toxicodendron spp.). Earlier, we reported the 3 resorcinol derivatives:heptade cadienylresorcinol (I), heptadecenylresorcinol (II) and pentadecylresorcinol (II I); collectively named ‘mangol’, as mango allergens. In this study, we extract ed the 1st 2 components (I and II) from the Philippine mango, adjusted them to 0 .05%concentration in petrolatum and patch tested the components on 2 subjects w ith mango dermatitis. Both subjects reacted to I. 1 subject also elicited a weak er positive reaction to II. To investigate the cross-reaction between mangol an d urushiol, we also patch tested the same subjects with urushiol. The subject sensitive to II reacted to urushiol. 6 subjects with a history of lacq uer contact dermatitis and positive reactions to urushiol were similarly patch t ested. 5 persons reacted to I. 2 subjects also exhibited a slower but positive r eaction to II. This is the 1st report in which heptadec(adi)enyl resorcinols kno wn to bepresent in man go have been shown to elicit positive patch test reaction s in mango-sensitive patients.
