摘要
It was demonstrated that both nociceptin, a novel opioid neuropeptide, and its receptor are present in trigeminovascular neurons. In an animal model nocicepti n dose-dependently inhibited neurogenic dural vasodilatation. These results sug gest that nociceptin may be involved in neurovascular headaches such as migraine . To test this hypothesis, we studied circulating nociceptin levels in 18 patien ts suffering from migraine without aura and in 24 controls. Headache-free migra ineurs had significantly lower nociceptin levels than controls (5.79±1.82 vs. 9.74±2.43 pg/ml, P < 0.0001, Student’s t-tests). Nociceptin levels were further reduced in six patients stu died in the first 3 h of typical migraine attacks (1.04±0.17 pg/ml). Nociceptin levels correlated with the frequency of attacks in this group of migraineurs. L ower interictal nociceptin levels may contribute to a defective regulation of tr igeminovascular neurons in migraineurs which might be important in the pain proc ess of migraine.
It was demonstrated that both nociceptin, a novel opioid neuropeptide, and its receptor are present in trigeminovascular neurons. In an animal model nocicepti n dose-dependently inhibited neurogenic dural vasodilatation. These results sug gest that nociceptin may be involved in neurovascular headaches such as migraine . To test this hypothesis, we studied circulating nociceptin levels in 18 patien ts suffering from migraine without aura and in 24 controls. Headache-free migra ineurs had significantly lower nociceptin levels than controls (5.79±1.82 vs. 9.74±2.43 pg/ml, P < 0.0001, Student's t-tests). Nociceptin levels were further reduced in six patients stu died in the first 3 h of typical migraine attacks (1.04±0.17 pg/ml). Nociceptin levels correlated with the frequency of attacks in this group of migraineurs. L ower interictal nociceptin levels may contribute to a defective regulation of tr igeminovascular neurons in migraineurs which might be important in the pain proc ess of migraine.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第9期36-37,共2页
Digest of the World Core Medical Journals:Clinical Neurology
