摘要
目的 评价类胰岛素生长因子结合蛋白 - 1预测临产时间的临床意义及其在先兆早产保胎中的价值。方法 比较IGFBP - 1和宫颈评分预测 72h内临产的成功性 ,比较先兆早产孕妇不同IGFBP - 1检测结果保胎效果的差异。结果 IGFBP - 1检测预测 72h内临产的敏感性、阴性预检值和准确性均高于宫颈评分 (P <0 0 1) ,假阴性率低于宫颈评分 (P <0 0 1)。先兆早产IGFBP - 1阴性者保胎均成功 ,阳性者保胎均失败。结论 IGFBP - 1试纸条预测临产时间明显优于宫颈评分 ,阳性可预测在 72h内临产。IGFBP - 1检测可预测先兆早产保胎成功性 ,指导临床医生采取相应治疗方案。
Objective:To study the clinical significance of insulin-like growth factor-binding protein-1 (IGFBP-1) in predicting the onset of dilivery.Methods:To study the successful rate of IGFBP-1 in predicting the onset of dilivery through the comparison with cervical Bishop score(CBS)and the application of IGFBP-1 in prediting the therapy effect to threated premature delivery. Results:The sensitivity,the negative predictive value and the accuracy of IGFBP-1 in predicting the onset of dilivery were higher significantly than those of CBS (P<0 01).The false negative rate of IGFBP-1 was lower significantly than that of CBS (P<0 01).After therapy,the negative cases in IGFBP-1 testing with threated premature delivery could continue pregnancy till at term.But the positive cases failed.Conclusion:For delivery prediction,IGFBP-1 is better than cervical Bishop score.It could predict the onset of delivery in 72 hours.To threated premature delivery,IGFBP-1 testing may predict therapy effect.
出处
《中国优生与遗传杂志》
2002年第4期56-57,53,共3页
Chinese Journal of Birth Health & Heredity
